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Renal circadian rhythm dysregulation in lupus nephritis

ABSTRACT: Renal circadian rhythm dysregulation in lupus nephritis

PROVIDER: PRJNA545270 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9141490_1.fastq.gz	Fastqsanger.gz
	SRR9141490_2.fastq.gz	Fastqsanger.gz
	SRR9141500_1.fastq.gz	Fastqsanger.gz
	SRR9141500_2.fastq.gz	Fastqsanger.gz
	SRR9141510_1.fastq.gz	Fastqsanger.gz

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Renal circadian rhythm dysregulation in lupus nephritis [array]

Project description:Renal circadian rhythm dysregulation in lupus nephritis [array]

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Renal circadian rhythm dysregulation in lupus nephritis [RNA-seq]

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Renal circadian rhythm dysregulation in lupus nephritis [array]

Project description:This study examines the circadian gene expression of whole kidneys of young and nephritic NZB/W F1 mice

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Reversible dysregulation of renal circadian rhythm in lupus nephritis.

Project description:BackgroundWe have found disruption of expression of major transcriptional regulators of circadian rhythm in the kidneys of several mouse models of lupus nephritis. Here we define the consequence of this disturbance with respect to circadian gene expression and renal homeostatic function in a mouse model of lupus nephritis.MethodsMolecular profiling of kidneys from 47 young and 41 nephritic female NZB/W F1 mice was performed at 4 hourly intervals over a 24 h period. Disruption of major circadian transcriptional regulators was confirmed by qPCR. Molecular data was normalized and analyzed for rhythmicity using RAIN analysis. Serum aldosterone and glucose and urine sodium and potassium were measured at 4 hourly intervals in pre-nephritic and nephritic mice and blood pressure was measured every 4 h. Analyses were repeated after induction of complete remission of nephritis using combination cyclophosphamide and costimulatory blockade.ResultsWe show a profound alteration of renal circadian rhythms in mice with lupus nephritis affecting multiple renal pathways. Using Cosinor analysis we identified consequent alterations of renal homeostasis and metabolism as well as blood pressure dipper status. This circadian dysregulation was partially reversed by remission induction therapy.ConclusionsOur studies indicate the role of inflammation in causing the circadian disruption and suggest that screening for loss of normal blood pressure dipping should be incorporated into LN management. The data also suggest a potential role for circadian agonists in the treatment of lupus nephritis.

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Renal circadian rhythm dysregulation in lupus nephritis

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Project description:Identification of cyclical expressed coding and non-coding genes during the circadian rhythm in NIH3T3 cells. NIH3T3 cells were synchronized for their circadian rhythm and RNA sequencing were performed at several time points along the rhythm. This data was used to identify cyclical expressed genes as well as long intergenic non-coding RNAs. NIH3T3 cells were synchronized with 100 nM Dexamethasone for 2 hours, then medium was changed to normal culture medium (0h). Every 4 hours cells were harvested, RNA isolated and RNAseq performed.

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