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Changes in total RNA in BK deficient mice after 4h sleep deprivation [pools]

ABSTRACT: Changes in total RNA in BK deficient mice after 4h sleep deprivation [pools]

PROVIDER: PRJNA545848 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9179391.fastq.gz	Fastqsanger.gz
	SRR9179392.fastq.gz	Fastqsanger.gz
	SRR9179393.fastq.gz	Fastqsanger.gz
	SRR9179394.fastq.gz	Fastqsanger.gz

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Changes in total RNA in BK deficient mice after 4h sleep deprivation [pools]

Project description:Animals deficient for the alpha subunit of the large conductance calcium dependent potassium channel (BK) were sleep deprived for 4 hours and compared to wildtype littermates as well as animals (wildtype littermate and BK deficient) left undisturbed for the same time.

2019-07-31 | GSE132075 | GEO

Changes in total RNA in BK deficient mice after 4h sleep deprivation

Project description:Changes in total RNA in BK deficient mice after 4h sleep deprivation

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Changes in total RNA in BK deficient mice after 4h sleep deprivation [individuals]

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Changes in total RNA in BK deficient mice after 4h sleep deprivation [individuals]

Project description:Changes in total RNA in BK deficient mice after 4h sleep deprivation [individuals]

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Microglia protect memories formed during sleep deprivation

Project description:Purpose: To determine the specific effects of 6 hours sleep deprivation after a learning event on the transcriptomes of microglia. Sleep deprivation can generate inflammatory responses in the neuronal environment. In turn, this inflammation increases sleep drive, leading to a rebound in sleep duration. Microglia, a type of support cell found exclusively in the brain, have previously been found to release of inflammatory signals and exhibit altered characteristics in response to sleep deprivation. Together, this suggests microglia may be partially responsible for the brain’s response to sleep deprivation through their inflammatory activity. In this study, we fully and selectively ablated microglia from the mouse brain and assessed resulting sleep, circadian, and sleep deprivation phenotypes. We find microglia are dispensable for both homeostatic sleep and circadian function and the sleep rebound response to sleep deprivation. However, we uncover a phenomenon by which microglia appear to be essential for the protection of synapses and associated memories formed during a period of sleep deprivation, further expanding the list of known functions for microglia in synaptic modulation.

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Project description:Analysis of the effects of sleep deprivation, recovery sleep, and three time-of-day controls on seven brain regions laser microdissected from mouse brain. The regions include the locus coeruleus, suprachiasmatic nucleus, hypocretin area, tuberomammillary nucleus, orbital cortex, posteromedial cortical amygdala, and entorhinal cortex. In this study, 7 brain regions were collected by laser microdissection from brain tissue of mice from 5 different treatment groups and used for microarray experiments. Four biological replicates were generated for each regionxcondition. Conditions are: SD, sleep deprivation for 6 hours from ZT0 - 6; SDC, time-of-day control for SD at ZT6; RS, recovery sleep for 4 hours following SD; RSC, time-of-day control for RS at ZT10; W, spontaneous waking at ZT18.

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