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Anteroposterior Wnt-RA Gradient define adhesion and migration properties of neural progenitors in developing spinal cord

ABSTRACT: Anteroposterior Wnt-RA Gradient define adhesion and migration properties of neural progenitors in developing spinal cord

PROVIDER: PRJNA545902 | ENA |

REPOSITORIES: ENA

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Anteroposterior Wnt-RA Gradient define adhesion and migration properties of neural progenitors in developing spinal cord

Project description:NPCs adhesion affinity along the AP axis is under the control of Wnt/RA molecular networks Caudal NPCs express a high amount of ECM genes compare to rostral-NPCs.

2019-06-04 | GSE132089 | GEO

Anteroposterior Wnt-RA Gradient Defines Adhesion and Migration Properties of Neural Progenitors in Developing Spinal Cord.

Project description:Mammalian embryos exhibit a transition from head morphogenesis to trunk elongation to meet the demand of axial elongation. The caudal neural tube (NT) is formed with neural progenitors (NPCs) derived from neuromesodermal progenitors localized at the tail tip. However, the molecular and cellular basis of elongating NT morphogenesis is yet elusive. Here, we provide evidence that caudal NPCs exhibit strong adhesion affinity that is gradually decreased along the anteroposterior (AP) axis in mouse embryonic spinal cord and human cellular models. Strong cell-cell adhesion causes collective migration, allowing AP alignment of NPCs depending on their birthdate. We further validated that this axial adhesion gradient is associated with the extracellular matrix and is under the control of graded Wnt signaling emanating from tail buds and antagonistic retinoic acid (RA) signaling. These results suggest that progressive reduction of NPC adhesion along the AP axis is under the control of Wnt-RA molecular networks, which is essential for a proper elongation of the spinal cord.

| S-EPMC7562945 | biostudies-literature

Rhodothermaceae bacterium RA strain:RA

Project description:Rhodothermaceae bacterium RA strain:RA Genome sequencing

| PRJNA308615 | ENA

Phosphoproteome of RA-responsive and RA-resistant breast cancer cell lines

Project description:Retinoic acid (RA), the main active vitamin A metabolite, controls multiple biological processes such as cell proliferation and differentiation through genomic programs and kinase cascades activation. Due to these properties, RA has proven anti-cancer capacity. Several breast cancer cells respond to the antiproliferative effects of RA, while others are RA-resistant. However, the overall signaling and transcriptional pathways that are altered in such cells have not been elucidated. Here, in a large-scale analysis of the phosphoproteins and in a genome-wide analysis of the RA-regulated genes, we compared two human breast cancer cell lines, a RA-responsive one, the MCF7 cell line, and a RA-resistant one, the BT474 cell line, which depicts several alterations of the "kinome".

2016-07-05 | PXD004357 | Pride

Phosphoproteome of RA-responsive and RA-resistant breast cancer cell lines

2020-10-15 | PXD005911 | Pride

Project description:WTCCC1 project Rheumatooid arthritis (RA) samples

| EGAD00000000007 | EGA

Meis genes regulate RA/FGF signaling to control multiple steps of limb development

Project description:Vertebrate limbs develop by integrating signals that control patterning along three main orthogonal axes. Flank-produced retinoic acid (RA) is initially required for limb induction and establishment of the apical ectodermal ridge (AER), a distal signaling center that produces fibroblast growth factors (FGFs), which are essential for limb growth and distalization. Once the AER is established, RA:FGF antagonism determines the restricted expression of a set of genes that control limb proximodistal patterning. Essential for this antagonism is the activation by FGF of the RA-degrading enzyme CYP26B1 in the distal limb bud. In addition, sonic hedgehog produced from the zone of polarizing activity (ZPA) is essential for distal limb anteroposterior patterning and contributes to RA reduction by cooperating in CYP26B1 activation. Meis transcription factors are expressed in the proximal limb bud, are activated by RA and can regulate proximodistal limb development; however, the mechanisms underlying their activity remain unknown. Here we studied Meis function in the mouse limb bud through Meis2 conditional overexpression and elimination of Meis1 and Meis2. We found that Meis activity is first required for limb bud initiation and the proper establishment of the AER and ZPA signaling centers, and subsequently for the development of proximal limb structures. Functional genomic analyses reveal that Meis is an important conveyor of the RA:FGF antagonism through the regulation of components of the RA and FGF signaling pathways, including CYP26B1. In addition, Meis regulates a set of proximal limb genes controlling proximodistal patterning and differentiation. Our work reveals a regulatory module essential for limb patterning and potentially co-opted in other patterning processes involving RA:FGF antagonism.

2018-09-25 | GSE51374 | GEO

Bicoid binding along anteroposterior axis of Drosophila Melanogaster embryos

Project description:Bicoid binding along anteroposterior axis of Drosophila Melanogaster embryos

| PRJNA404072 | ENA

Mammalian Pumilio Proteins Control Cellular Morphology, Migration, and Adhesion

Project description:Mammalian Pumilio Proteins Control Cellular Morphology, Migration, and Adhesion

| PRJNA857310 | ENA

Analysis of RA vs 4-oxo-RA gene expression regulation in Xenopus laevis

Project description:We analyzed anterior halves of NF stage 15 embryos that were treated with 10uM DMSO (control), or 1uM RA and 10uM 4-oxo-RA (experimental) for changes in gene expression induced by the two mophogens. RNA-sequencing revealed significant overlap in genes upregulated by both RA and 4-oxo-RA, and to a lesser extent, those downregulated by them. We report all Zic-1 targets described in accompanying manuscript to be regulated by both RA and 4-oxo-RA.

2022-03-09 | GSE180269 | GEO

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