Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

ABSTRACT: RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

PROVIDER: PRJNA546280 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9201800.fastq.gz	Fastqsanger.gz
	SRR9201810.fastq.gz	Fastqsanger.gz
	SRR9201820.fastq.gz	Fastqsanger.gz
	SRR9201830.fastq.gz	Fastqsanger.gz
	SRR9201801.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 38

Similar Datasets

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions (CAGE)

Project description:RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions (CAGE)

| PRJNA546284 | ENA

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions (RADICL-seq)

Project description:RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions (RADICL-seq)

| PRJNA546285 | ENA

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions (CAGE)

Project description:Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. To investigate the function of such RNAs,, methods to massively map the genomic interacting sites of multiple transcripts have been developed. However they present still some limitations. Here, we introduce RNA and DNA interacting complexes ligated and sequenced (RADICL-seq), a novel technology that maps genome-wide RNA-chromatin interactions in intact nuclei. RADICL-seq is a proximity ligation based methodology that reduces the bias for nascent transcription, increases genomic coverage and unique mapping rate efficiency compared to existing methods. RADICL-seq identifies distinct patterns of genome occupancy for different classes of transcripts as well as cell type-specific RNA-chromatin interactions, and emphasizes the role of transcription in the establishment of chromatin structure.

2019-12-05 | GSE132191 | GEO

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions (RADICL-seq)

2019-12-05 | GSE132190 | GEO

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions.

Project description:Mammalian genomes encode tens of thousands of noncoding RNAs. Most noncoding transcripts exhibit nuclear localization and several have been shown to play a role in the regulation of gene expression and chromatin remodeling. To investigate the function of such RNAs, methods to massively map the genomic interacting sites of multiple transcripts have been developed; however, these methods have some limitations. Here, we introduce RNA And DNA Interacting Complexes Ligated and sequenced (RADICL-seq), a technology that maps genome-wide RNA-chromatin interactions in intact nuclei. RADICL-seq is a proximity ligation-based methodology that reduces the bias for nascent transcription, while increasing genomic coverage and unique mapping rate efficiency compared with existing methods. RADICL-seq identifies distinct patterns of genome occupancy for different classes of transcripts as well as cell type-specific RNA-chromatin interactions, and highlights the role of transcription in the establishment of chromatin structure.

| S-EPMC7039879 | biostudies-literature

RADICL-seq identifies general and cell type-specific principles of genome-wide RNA-chromatin interactions

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-12-05 | GSE132192 | GEO

Physico-chemical principles of HDL-small RNA binding interactions

Project description:Physico-chemical principles of HDL-small RNA binding interactions

| PRJNA791204 | ENA

Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions.

Project description:Genomic maps of lincRNA occupancy reveal principles of RNA-chromatin interactions.

| PRJNA146003 | ENA

Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and pervasive recursive splicing

Project description:Dynamic imaging of nascent RNA reveals general principles of transcription dynamics and pervasive recursive splicing