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Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications [HTA-2_0]

ABSTRACT: Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications [HTA-2_0]

PROVIDER: PRJNA546536 | ENA |

REPOSITORIES: ENA

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Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications [HTA-2_0]

Project description:Hepatoblastoma (HB) is the predominant pediatric liver cancer with limited therapeutic options for patients with aggressive tumors. Nevertheless, it is a rare disease. Here, we performed a high-throughput molecular study of 32 patients with HB and major findings were validated in additional 80 cases. We unveiled an epigenetic footprint including downregulation of RNA-editing, hyperediting of the tumor suppressor BLCAP,14q32 DLK1-DIO3 locus overexpression, DNA hypomethylation and CpG island hypermethylation. Based on these findings, we defined an integrative molecular classification of HB that improve current clinical stratification, and identified CHKA as a therapeutic target for the poor prognostic subclass.

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Project description:Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications [CytoScanHD_Array]

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Project description:Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications [Infinium MethylationEPIC]

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Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications [RNA-seq]

Project description:Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications [RNA-seq]

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Epigenetic footprint of hepatoblastoma defines a novel integrative molecular classification with clinical implications

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-03-23 | GSE132219 | GEO