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ADAR1 overexpression in MDA-MB-231 cells

ABSTRACT: ADAR1 overexpression in MDA-MB-231 cells

PROVIDER: PRJNA547525 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9209780_1.fastq.gz	Fastqsanger.gz
	SRR9209780_2.fastq.gz	Fastqsanger.gz
	SRR9209781_1.fastq.gz	Fastqsanger.gz
	SRR9209781_2.fastq.gz	Fastqsanger.gz
	SRR9209782_1.fastq.gz	Fastqsanger.gz

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ADAR1 overexpression in MDA-MB-231 cells

Project description:Abstract: RNA editing has emerged as novel mechanisms involved in cancer progression. Despite the phenotypic implications of ADAR in several cancer models, the role of ADAR on DNA damage response (DDR) and proliferation in breast cancer (BC) has not been fully addressed. To evaluate the effect of ADAR expression, MDA-MB-231 cells were transduced (MOI:200) with commercial pre-package adenoviral particles coding for ADARp110 or transduced (MOI:200) with eGFP control adenovirus. 16 h after transduction media was changed and RNA were extracted 48 h after transduction. ADARp110 overexpression produces a significant increase in transcripts related with cell cycle and proliferative pathways, in addition to other pathways related to IL10 signaling, among others. In other hand 657 sites significantly increase their editing in MDA-MB-231 OV cells at site level comparison. Conversely, transcripts involved in Generic Transcription, cell cycle, HIV life Cycle related pathways and Apoptosis suffer an increased editing ratio, suggesting that ADAR activity could be is in the regulation of the targets that bears significant changes in their editing pattern after ADAR manipulation

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Effect of ARL11 overexpression on gene expression of MDA-MB-231 cells during olaparib treatment

Project description:To investigate the function ARL11 in the regulation of PARPi resistance, we established MDA-MB-231 cells overexpressing ARL11. We then performed gene expression profiling analysis using data obtained from RNA-seq of ARL11 overexpression or vector control MDA-MB-231 cells treated with or without Olaparib.

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Project description:LRP-1 (low-density lipoprotein receptor-related protein-1) receptor is a multifunctional endocytosis receptor that is part of the LDL receptor family. Due to its capacity to control the pericellular level of various growth factors and proteases, LRP-1 plays a crucial role in controlling the dynamics of the membrane proteome. LRP-1 overexpression in breast cancer, prompted us to take an interest in its involvement in tumor progression. An RNA interference strategy in MDA-MB-231 line was used, based on shRNA stable expression. In addition to integrated experimental strategies (in vitro and in vivo) through combined approaches of biochemistry, molecular biology, cell biology, multimodal preclinical imaging, proteomics allowed us to compare shLRP-1 MDA-MB-231 tumor conditioned media to shCtrl MDA-MB-231 tumor conditioned media in order to identify secreted molecular targets modulate by LRP-1 repression and thus provide a better understanding of its regulatory action within the TNBC microenvironment.

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Project description:PRRX1 overexpression in MDA-MB-231 breast cancer cells

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FBP1 overexpression in MDA-MB-231 breast cancer cells

Project description:FBP1 overexpression in MDA-MB-231 breast cancer cells

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Expression profiles of MDA-MB-231, MDA-231 S1a and S1b

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