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The fate switch between ON and OFF SACs is determined by Fezf1

ABSTRACT: The fate switch between ON and OFF SACs is determined by Fezf1

PROVIDER: PRJNA548195 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9264360_1.fastq.gz	Fastqsanger.gz
	SRR9264360_2.fastq.gz	Fastqsanger.gz
	SRR9264370_1.fastq.gz	Fastqsanger.gz
	SRR9264370_2.fastq.gz	Fastqsanger.gz
	SRR9264380_1.fastq.gz	Fastqsanger.gz

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Binary Fate Choice Between Closely Related Interneuronal Types is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch

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The fate switch between ON and OFF SACs is determined by Fezf1

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Project description:Establishment and maintenance of CNS glial cell identity ensures proper brain development and function, yet the epigenetic mechanisms underlying glial fate control remain poorly understood. Here we show that the histone deacetylase Hdac3 controls oligodendrocyte-specification gene Olig2 expression, and functions as a molecular switch for oligodendrocyte and astrocyte lineage determination. Our data suggest that Hdac3 cooperates with p300 to prime and maintain oligodendrogenic programs while inhibiting Stat3-mediated astrogliogenesis, and thereby regulate phenotypic commitment at the point of oligodendrocyte-astrocytic fate decision. Gene expression profiling of optic nerve from P12 control and Hdac3 cKO mice

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Project description:Many neuronal types occur as pairs that are similar in most respects but differ in a key feature. In some pairs of retinal neurons, called paramorphic, one member responds to increases and the other to decreases in luminance (ON and OFF responses). Here, we focused on one such pair, starburst amacrine cells (SACs), to explore how closely related neuronal types diversify. We find that ON and OFF SACs are transcriptionally distinct prior to their segregation, dendritic outgrowth, and synapse formation. The transcriptional repressor Fezf1 is selectively expressed by postmitotic ON SACs and promotes the ON fate and gene expression program while repressing the OFF fate and program. The atypical Rho GTPase Rnd3 is selectively expressed by OFF SACs and regulates their migration but is repressed by Fezf1 in ON SACs, enabling differential positioning of the two types. These results define a transcriptional program that controls diversification of a paramorphic pair.

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