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Homo sapiens

ABSTRACT: Gene expression data of human nasopharyngeal carcinoma (NPC)

PROVIDER: PRJNA548225 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9302171_1.fastq.gz	Fastqsanger.gz
	SRR9302171_2.fastq.gz	Fastqsanger.gz
	SRR9302172_1.fastq.gz	Fastqsanger.gz
	SRR9302172_2.fastq.gz	Fastqsanger.gz
	SRR9302173_1.fastq.gz	Fastqsanger.gz

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Project description:Nasopharyngeal carcinoma (NPC) remains a majoy health problem worldwide, specially in Southeast China. In order to find the new candidate genes and molecular markers that are associated with nasopharyngeal carcinoma (NPC), this study focused on the screening NPC relative genes by gene expression profile. Keywords: disease state analysis 23 NPC biopsies and 15 nasopharynx chronic phlogistic biopsies were used to screen NPC relative genes by BioStarH-141s (2004) profile gene chips which contained 14112 points of full length human genes. The tumor samples were labeled with Cy5-dUTP.The nasopharyngeal phlogistic tissues were labeled with Cy3-dUTP. Biostatistics and bioinformatics were also used to analyse the differently expressed genes.

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Project description:Expression data from biopsies of Nasopharyngeal carcinoma (NPC) and non-malignant controls

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Project description:MicroRNAs are biomarkers of prognosis and survival for many types of cancer. We evaluated whether microRNAs can predict the survival and efficacy of concurrent chemotherapy in nasopharyngeal carcinoma (NPC) patients. We retrospectively analyzed microRNA expression in 312 paraffin-embedded NPC specimens and 18 normal nasopharyngeal tissues using microarray. We found Forty-one microRNAs are differentially expressed between NPC and normal tissues, and a five-microRNA signature can predict survival independent of stage. NPC patients with the low-risk microRNA signature have a favorable response to concurrent chemotherapy. microRNA profiling of nasopharyngeal carcinoma tissues vs. normal nasopharyngeal tissues 312 paraffin-embedded nasopharyngeal carcinoma tissues and 18 paraffin-embedded normal nasopharyngeal tissues

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