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The pituitary hormonal changes related to feed efficiency in pigs

ABSTRACT: The pituitary hormonal changes related to feed efficiency in pigs

PROVIDER: PRJNA548282 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9265660.fastq.gz	Fastqsanger.gz
	SRR9265670.fastq.gz	Fastqsanger.gz
	SRR9265661.fastq.gz	Fastqsanger.gz
	SRR9265662.fastq.gz	Fastqsanger.gz
	SRR9265663.fastq.gz	Fastqsanger.gz

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The pituitary hormonal changes related to feed efficiency in pigs

Project description:In Poland, conducted for years porcine breeding works focused on improving meat content in the carcass without undertaken to accomplish the more effectiveness of fattening indicators that impact on feed efficiency. At present, feeding and feed conversion became important factors that are especially evident in the countries where the production of fattening pigs is conducted in large farms. In the present study, was attempted to indicate pituitary candidate genes depending on feed conversion ratio (FCR) in native Polish pig breed, Złotnicka White. The whole pituitary transcriptome was sequenced using next-generation sequencing technology. The obtained results show the differences in gene expression for pathways associated with hormonal regulation and also with Notch and Wnt signaling. Moreover, it was observed that worse FCR in Złotnicka pigs was associated with a higher fat level in a carcass and a significant higher level of prolactin expression in the pituitary.

2019-06-12 | GSE132522 | GEO

Ileal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of ileum (mucosa) obtained from pigs divergent in feed efficiency

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Caecal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of caecum (mucosa) obtained from pigs divergent in feed efficiency

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Hypothalamic transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of the hypothalamus obtained from pigs divergent in feed efficiency.

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Ileal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of ileal scratchings (mucosa) obtained from pigs divergent in feed efficiency.

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Jejunal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of jejunal scratchings (mucosa) obtained from pigs divergent in feed efficiency.

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Duodenal transcriptome profiles of pigs divergent in feed efficiency

Project description:in vivo microarray study of transcriptional changes of duodenum scratchings (mucosa) obtained from pigs divergent in feed efficiency.

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Transcriptional patterns of pigs divergent in feed efficiency traits

Project description:in vivo microarray study to detect transcriptional changes in muscle tissue (M. longissimus) derived from pigs divergent in feed efficiency.

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Pituitary transcriptomic changes dependent on feed conversion in pigs

Project description:Purpose: RNA-seq method was applied to select genes expressed in feed conversion in pigs and pinpointed genes potentially associated with this feature. Methods: The whole pituitary samples were collected from 16 Puławska pigs (8 pigs per two groups - with high and low feed conversion) maintained at the same environmental and feeding condition. The RNA-seq analysis was performed in 90 single-end cycles on HiScanSQ platform (Illumina) and differentially expressed genes (DEGs) were determined using Deseq2 software. Validation was performed for 10 randomly selected genes using real-time PCR method. Results: The study showed that in pigs characterized by better feed conversion 274 genes were differentially expressed. Genes showed decreased expression encode proteins associated with cholesterol metabolism (APOA1, CH25H, APOE) and regulation of hormone levels (POMC, CTSZ, ADM, AGTR1, SOX8, AGT, CPT1, APOA1, GJA1, MYRIP, CYP1B1, NR1D1). Four genes showed over the 10-fold decrease of expression (CRYM, ISM1 and WNK4), where the CRYM protein binds thyroid hormone for regulatory and developmental roles and WNK4 regulates the balance between NaCl reabsorption and K(+) secretion. In turn, genes showed an increase of expression in the pituitary of pigs having better feed conversion encode proteins were related to cellular response to corticotropin-releasing hormone stimulus (NR4A1, NR4A2, NR4A3) and regulation of type B pancreatic cell proliferation (BIRC5, NR4A3, NR4A1). Conclusions: The present study indicates new genes potentially related to feed conversion, which is one of the most economically important traits in pig breeding. The selected genes should be investigated in future in the terms of their association with fattening traits. The study was financed from funds of the project -BIOSTRATEG, the decision number BIOSTRATEG2/297267/14/NCBR/2016.

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Integrating multi-omics data to identify key functional variants affecting feed efficiency in pigs

Project description:Optimizing feed efficiency through the feed conversion ratio (FCR) is paramount for economic viability and sustainability. In this study, we integrated RNA-seq, ATAC-seq, and genome-wide association study (GWAS) data to investigate key functional variants associated with feed efficiency in pigs. Identification of differentially expressed genes in the duodenal and muscle tissues of low- and high-FCR pigs revealed that pathways related to digestion of dietary carbohydrate are responsible for differences in feed efficiency between individuals. Differential open chromatin regions identified by ATAC-seq were linked to genes involved in glycolytic and fatty acid processes. GWAS identified 211 significant single nucleotide polymorphisms associated with feed efficiency traits, with candidate genes PPP1R14C, TH, and CTSD. Integration of duodenal ATAC-seq data and GWAS data identified six key functional variants, particularly in the 1500985–1509676 region on chromosome 2. In those regions, CTSD was found to be highly expressed in the duodenal tissues of pigs with a high feed conversion ratio, suggesting its role as a potential target gene. Overall, the integration of multi-omics data provided insights into the genetic basis of feed efficiency, offering valuable information for breeding more efficient pig breeds.

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