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Gene expression of donor monocytes recovered from various tissues of recipient mice one day after transfer

ABSTRACT: Gene expression of donor monocytes recovered from various tissues of recipient mice one day after transfer

PROVIDER: PRJNA548331 | ENA |

REPOSITORIES: ENA

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Gene expression of donor monocytes recovered from various tissues of recipient mice one day after transfer

Project description:Monocyte are recruited to almost all peripheral tissues. Micro-environmental stimuli appeared to alter monocyte transcription once they enter the intestine and their subsequent development in the tissue. We therefore investigated whether there is tissue specific monocyte adaption and differentiation in vivo by examining donor monocytes in various tissues i.e. small intestine, liver, spleen and BM.

2019-06-12 | GSE132537 | GEO

Tnseq to identify recipient factor to modulate conjugative plasmid transfer

Project description:Tn insertion library was used for recipient for conjugative transfer of pESBL, F, and R388 plasmids. For both recipient and the resulting exconjugant libraries, Tn insertion sites were determined by illumina sequencing

2023-02-13 | E-MTAB-11704 | biostudies-arrayexpress

Transcriptomic analyis of donor (B6:SJL.C20) and host follicular and marginal zone B cells after adoptive transfer of follicular B cells into into lymphopenic (Rag2-/-) or replete animals (C57BL6)

Project description:The generation of marginal zone (MZ) B cells is a Notch2 dependent process. We observed that transdifferentiation of follicular (FO) B cells to an MZ-like phenotype is dependent on a lymphopenic environment. We therefore adoptively transftered congenically marked SJL.C20 (CD45.1) mature naive FO B cells into either lymphopenic Rag2-/- or intact C57BL6 (CD45.2) recipient mice and recovered and double sorted intermediate phenotype (MZ-FO) donor B cells at day 4 post transfer from Rag2-/- recipients or both MZ and FO phenotype donor B cells at day 8 post transfer from both recipient groups and performed RNA sequencing.

2022-05-01 | GSE200219 | GEO

Expression in donor monocyte derived cells

Project description:Monocyte differentiate into macrophages that display either pro-inflammatory or tolerogenic profile depending on the inflammatory condition of the intestine. We performed adoptive monocyte transfer to dissect the dynamics of monocyte to macropahges differentiation. Gene expression analysis of donor monocyte-derived cells recovered from non-inflamed and inflamed small intestine of recipient mice at day 1, 2 and 5 after transfer for in-depth investigation of monocyte development in the intestine.

2019-06-12 | GSE132530 | GEO

Lateral transfer of mRNA by migrasomes modifies the recipient cell

Project description:Lateral transfer of mRNA by migrasomes modifies the recipient cell

| PRJNA541291 | ENA

Tnseq to identify recipient factor to modulate conjugative plasmid transfer

Project description:Tnseq to identify recipient factor to modulate conjugative plasmid transfer

| PRJEB52729 | ENA

scRNA-seq analysis of mouse splenic CD8 T cells 1 month post transfer of CD8 T cells from 3 months old donor into 24 months old recipient

Project description:Aging is associated with systemic chronic inflammation (inflammaging) that leads to impaired physiological functions and vulnerability to several diseases. However, underlying alterations in aged immune system resulting in gradual loss of immune fitness remain unclear. Using a combination of CD8 T cell transfer from young to old and from old to young mice and single-cell RNA sequencing, we characterized the age-associated alterations in CD8 T cells. We transferred 2 millions of purified CD8+ T cells pooled from 3 CD45.1 C57BL/6J 3 months old female mice (donor) by i.v. injection into CD45.2 C57BL/6J 24 months old female mouse (recipient) and sorted CD45.1+CD3e+CD8a+ and CD45.2+CD3e+CD8a+ T cells from the spleen 1 month post transfer to perform scRNA/TCR-seq.

2020-12-06 | GSE155005 | GEO

Donor non-classical monocytes recruit recipient classical monocytes from the spleen by activating donor alveolar macrophages

Project description:Donor non-classical monocytes recruit recipient classical monocytes from the spleen by activating donor alveolar macrophages

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Divalent cations promote the transfer of the IncP-7 plasmid pCAR1 among different Pseudomonas hosts

Project description:An incompatibility P-7 plasmid pCAR1 can be efficiently transferred among artificial microcosms in the presence of divalent cations Ca2+ and Mg2+. One on one mating assays between Pseudomonas strains with different plasmids showed that the promotion of transfer efficiency by divalent cations was also found in other plasmids including pB10 and NAH7, whereas the impacts were larger in IncP-7 plasmids. The impact on pCAR1 transfer altered by different pairs of donor and recipient strains, and the promotion of transfer efficiency was clearly detected between donors P. resinovorans CA10dm4 and P. fluorescens Pf0-1 to the recipients P. putida KT2440 and CA10dm4. Transcriptome analyses showed that genes on the pCAR1 did not respond to the presence of cations, including the tra/trh genes involved in its transfer. Notably, transcriptions of oprH genes, encoding a putative outer membrane proteins, in both of donor and recipient were commonly upregulated under the cation-limited condition. Transfer frequency of the pCAR1 to the transposon mutant of oprH in KT2440 was not promoted by the cations. This effect was partially recovered by the complementation with oprH gene, suggesting that OprH is involved in the promotion the pCAR1 transfer by divalent cations.

2017-04-11 | GSE97565 | GEO

Small intestinal inflammation shapes the transcriptomic signature of incoming monocytes in a partially Trem1-dependent mechanism

Project description:In this study we showed that Trem1 is one of genes that were differentially regulated in donor monocytes recovered from non-inflamed and inflamed small intestine of recipient mice. We, therefore, aimed at investigating the role of Trem1 on regulating the monocyte adapatation and differentiation in a context-dependent manner. Thus, the gene expression of WT and Trem1-deficient donor monocytes that are recruited to non-inflamed and inflamed small intestine one day after transfer.

2019-06-12 | GSE132549 | GEO

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