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Human PI3KGamma deficiency with immunodeficiency and tissue immunopathology

ABSTRACT: Human PI3KGamma deficiency with immunodeficiency and tissue immunopathology

PROVIDER: PRJNA548604 | ENA |

REPOSITORIES: ENA

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Human PI3KGamma deficiency with immunodeficiency and tissue immunopathology

Project description:Human PI3KGamma deficiency with immunodeficiency and tissue immunopathology

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Human PI3Kγ Deficiency with Immunodeficiency and Tissue Immunopathology

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Project description:Clinically, obesity is strongly associated with severe TH2 immunopathology, though the physiological, cellular, and molecular underpinnings of this association remain obscure. We demonstrate that obese mice are susceptible to severe atopic dermatitis (AD), a major manifestation of TH2 immunopathology and disease burden in humans. Mechanistically, we show that dysregulation of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARg) in T cells is a causal link between obesity and the increased TH2 immunopathology. We find that PPARg directly controls a cellular metabolic transcriptional program that restrains nuclear gene expression of the chief TH2 effector cytokines interleukin-4 (IL-4) and interleukin-13 (IL-13). Accordingly, thiazolidinediones (TZDs), potent PPARg agonists, robustly protect obese mice from TH2 immunopathology. Collectively, these findings establish PPARg as a molecular link between obesity and TH2 immune homeostasis and identify TZDs as novel therapeutic candidates for TH2 immunopathology.

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