Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptional alterations in BPH

ABSTRACT: Transcriptional alterations in BPH

PROVIDER: PRJNA548798 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9298760_1.fastq.gz	Fastqsanger.gz
	SRR9298760_2.fastq.gz	Fastqsanger.gz
	SRR9298770_1.fastq.gz	Fastqsanger.gz
	SRR9298770_2.fastq.gz	Fastqsanger.gz
	SRR9298761_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 44

Similar Datasets

Transcriptional alterations in BPH

Project description:We identified a BPH transcriptional signature that included 392 significantly differential expressed genes between BPH and control samples, and validated this BPH transcriptional signature using two independent study cohorts. By performing integrative analysis using transcriptional and methylation profiling, we identified two distinct BPH subtypes, supporting robust biologically distinct subgroups across different data types. To validate these BPH subtypes, we tested our signature via k-means clustering in two independent cohorts, and identified nearly identical subgroups. To nominate potential subtype specific therapeutic options, we utilized a Connectivity Map analysis, and found 50% of nominated compounds in one subgroup were related to inhibition of mTOR signaling.

2020-03-18 | GSE132714 | GEO

Copy number analysis of BPH (Benign Prostatic Hyperplasia)

Project description:BPH samples harbored minimal copy number alterations, and the fraction of altered genome was far lower than primary prostate cancer and other neoplastic diseases.

2020-03-18 | GSE124187 | GEO

Transcriptome analysis of BPH-resistant and BPH-susceptible rice seedlings in response to BPH infestation

Project description:Transcriptome analysis of BPH-resistant and BPH-susceptible rice seedlings in response to BPH infestation. RH vs. 02428: a microarray analysis of genes that were differentially expressed in a BPH-resistant cultivar, Rathu Heenati (RH) and a susceptible cultivar 02428 after infestation with BPH for 24h. RB vs. SB: a microarray analysis of genes that were differentially expressed in resistant seedling pool and susceptible seedling pool both infested with BPH for 24h. RB vs. RN: a microarray analysis of genes that were differentially expressed in resistant seedling pool infested with BPH for 24h and resistant seedling pool without BPH infestation. Goal was to explore the molecular basis underlying BPH-resistance in rice.

2019-11-19 | GSE140562 | GEO

10x BPH sequencing

Project description:10x BPH sequencing

| PRJNA691578 | ENA

Transcriptome analysis of BPH-resistant and BPH-susceptible rice seedlings in response to BPH infestation

Project description:Transcriptome analysis of BPH-resistant and BPH-susceptible rice seedlings in response to BPH infestation

| PRJNA590181 | ENA

10x BPH sequencing

Project description:Single-cell mRNA sequencing (scRNA-seq) study was conducted to to probe heterogeneity of human BPH associated leukocytes

2022-02-16 | GSE164695 | GEO

10x BPH sequencing on all cells

Project description:Single-cell mRNA sequencing (scRNA-seq) study was conducted to to probe heterogeneity of human BPH associated cells. No cell sorting was conducted so all cells within the BPH environment could be represented.

2022-02-16 | GSE183676 | GEO

Expression data from Incidental vs. Surgical BPH samples

Project description:used to identify differences between tissues from patients undergoing surgery for BPH with unresolved symptoms compared to incidental BPH from patients with prostate cancer

2015-01-27 | GSE65343 | GEO

Expression data from brown planthhoper (BPH) infested and non-infested rice

Project description:KMD is genetically engenered to be highly resistant to lepidopteran pests through expressing a synthetic cry1Ab gene and its parent non-transgenic rice is Xiushui 11.The developmental duration of BPH feeding on KMD2 was significantly delayed. And moreover, the fecundity of BPH was significantly lower when fed on Bt rice than on the non-Bt parental plants.To investigate unintended effects in KMD2 that causes changes in BPH performance, we performed microarray (GeneChip) analysis to compare the gene expression profiles between Bt rice and non-transgenic parental plants in response to BPH infestation. We used microarrays to detect Bt-independent variation, which might render Bt rice more defensive or less nutritious to BPH. For BPH treatment, 10 second-instar nymphs were infested onto each 30-day-old seedling. After 72 h, the BPH nymphs were carefully removed and rice shoots of both BPH-infested and non-infested plants were sampled for microarray analysis. There were four treatments: Xiushui 11-non infested, Xiushui 11-BPH infested, KMD2-non infested, KMD2-BPH infested, three biological replications.

2015-11-06 | E-GEOD-74745 | biostudies-arrayexpress

Enhanced Reduced Representation Bisulfite Sequencing of BPH and control samples

Project description:We investigated the epigenetic landscape of benign prostatic hyperplasia (BPH) by defining the DNA methylation profile of 18 BPH samples and 5 controls from normal transitional zone. We identified 92,046 hypermethylated CpG and 10,117 hypomethylated CpG across different genomic regions in BPH, and hypermethylation was the dominant signal across all genomic regions, even when controlling for bias of CpG-rich loci. We defined a methylation signature for BPH that included 696 differentially methylated CpGs in promoter regions.

2020-03-18 | GSE123111 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data