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In vivo evaluation of the 94 GHz-chronic exposure effect on Hairless rat skin gene expression

ABSTRACT: In vivo evaluation of the 94 GHz-chronic exposure effect on Hairless rat skin gene expression

PROVIDER: PRJNA549165 | ENA |

REPOSITORIES: ENA

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In vivo evaluation of the 94 GHz-chronic exposure effect on Hairless rat skin gene expression [C2]

Project description:Millimeter waves are new broadband frequencies that start to be used in several applications such as future wireless communications, medical, and also non-lethal weapons (the 94-GHz band in Active Denial Systems). However, low information are available on their potential effects on human. These frequencies belong to radiofrequency and they have the property to be stopped by the first layer of the skin. Therefore our studies have aimed to evaluate 94 GHz effects on skin cells whole gene expression. Chronic long term 94 GHz MMW exposures were performed on two rat populations constituted by 17 young animals and 14 adult ones. Each group of animals were equally split in Exposed and Sham exposed subgroup. This two independent exposure experiments were conducted during 5 months, with rats exposed 3 h per day, 3 days per week, to an incident power density of 10 mW/cm², which correspond to twice the ICNIRP limit of exposure for professional. At the end of the experiment, skin explant were taken and RNA were extracted. Then, the modification of the whole gene expression were analyzed with gene expression microarray. Without modification of the animal’s temperature, long term chronic 94 GHz-MMW exposure did not significantly modify the rat’s skin gene expression on both young and adult rats.

2021-01-13 | GSE132817 | GEO

In vivo evaluation of the 94 GHz-chronic exposure effect on Hairless rat skin gene expression [C1]

2021-01-13 | GSE132816 | GEO

In vivo evaluation of the 94 GHz-chronic exposure effect on Hairless rat skin gene expression [C2]

Project description:In vivo evaluation of the 94 GHz-chronic exposure effect on Hairless rat skin gene expression [C2]

| PRJNA549169 | ENA

In vivo evaluation of the 94 GHz-chronic exposure effect on Hairless rat skin gene expression [C1]

Project description:In vivo evaluation of the 94 GHz-chronic exposure effect on Hairless rat skin gene expression [C1]

| PRJNA549168 | ENA

In vivo evaluation of the 94 GHz-chronic exposure effect on Hairless rat skin gene expression

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-01-13 | GSE132818 | GEO

On the effects of 30 GHz sinusoidal wave exposure on glioblastoma organoids

Project description:In this study, we evaluated the effects of milli-meter waves on structured Glioblastoma organoids to assess the possibility of therapeutic applications. The exposure setup was completely developed, and the dosimetry carried on based on both numerical and experimental activities. Our results showed that continuous milli-meter waves at 30.5 GHz affect cell proliferation and apoptosis, thus not affecting the differentiation status of the organoids composing of GBM cells. By applying the power level of 0.1 W (RMS), we obtain a synergistic effect with the chemotherapeutic Temozolomide in terms of GBM cell death. All these data open the way to an interventional window in which to treat GBM cells (i.e. with TMZ) exploiting 30.5 GHz CW exposure for potential therapeutic purposes thus improving GBM future management, which remain extremely difficult so far. Our investigation sheds light on the characterization of possible bio-effects of MMW (30.5 GHz CW) on GBM organoids highlighting cell and molecular responses in a relevant 3D tumor model.

2024-07-01 | GSE239486 | GEO

Changes of protein expression after long term exposure to 2.856 GHz and 9.375 GHz microwaves

Project description:Changes of protein expression in hippocampus after long term exposure to 2.856 GHz and 9.375 GHz microwaves

2022-08-19 | PXD036155 |

Streptomyces sp. 94 strain:94

Project description:Streptomyces sp. 94 strain:94 Genome sequencing

| PRJNA402579 | ENA

Mucilaginibacter sp. 94 strain:94

Project description:Mucilaginibacter sp. 94 strain:94 Genome sequencing

| PRJNA463439 | ENA

Expression changes in Hairless depleted Kc cells

Project description:Several co-repressors interact directly with the DNA-binding protein CSL [Su(H) in Drosophila] and are proposed to keep target genes silenced in the absence of Notch activity. To investigate co-repressor activity in the context of this well defined signalling pathway, we analysed the genome-wide binding profile of the best-characterized CSL co-repressor in Drosophila, Hairless, in Kc cells and in wing imaginal discs. The binding profile in wing discs of a second CSL interacting repressor, SMRTER, was also analysed. There was significant overlap between Hairless and Su(H), both in Kc cells and in wing discs, where they were predominantly found in chromatin with active enhancer marks. The Hairless complex was widely present at some Notch regulated enhancers in the wing disc,but no binding was detected at others, indicating that it is not essential for silencing per se. Analysis of target enhancers confirmed differential requirements for Hairless. SMRTER binding significantly overlapped with Hairless, rather than complementing it, and many enhancers were apparently co-bound by both factors. Our analysis indicates that the actions of Hairless and SMRTER gate the enhancers to Notch activity and to Ecdysone signalling respectively, to ensure that the appropriate levels and timing of target gene expression are achieved.

2017-12-31 | GSE97597 | GEO

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