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Rfx6-regulated genes in the mouse intestine

ABSTRACT: Rfx6-regulated genes in the mouse intestine

PROVIDER: PRJNA549723 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9327320.fastq.gz	Fastqsanger.gz
	SRR9327321.fastq.gz	Fastqsanger.gz
	SRR9327312.fastq.gz	Fastqsanger.gz
	SRR9327322.fastq.gz	Fastqsanger.gz
	SRR9327313.fastq.gz	Fastqsanger.gz

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Rfx6-regulated genes in the mouse intestine

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Project description:The goal of this study was to identify genes which are differentiatlly expresesd upon induced inactivation of Rfx6 in beta cell in adult mice Rfx6fl/fl; Ins1-CreERT2 (mut) and Rfx6fl/fl (ctrl) 8 weeks old mice were injected subcutaneously with tamoxifen daily during 3 days. Pancreatic islets were isolated 5 days after the first injection and RNA purified.

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Rfx6 target genes in the Min6b1 cell line, a pancreatic beta cell model

Project description:Increasing evidence suggests that loss of beta cell characteristics may cause insulin secretory deficiency in diabetes but the underlying mechanisms remain unclear. Here we show that Rfx6, whose mutation leads to neonatal diabetes in man, is essential to maintain key features of functionally mature beta cells in mice. Rfx6 loss in adult beta cells leads to glucose intolerance, impaired beta cell glucose sensing and to defective insulin secretion. This is associated with reduced expression of core components of the insulin secretion pathway including GLucokinase, the Abcc8/SUR1 subunit of KATP channels and voltage-gated Ca2 channels, which are direct targets of Rfx6. Moreover, Rfx6 contributes to the silencing of the vast majority of “disallowed” genes, a group usually specifically repressed in adult beta cells, and thus to the maintenance of beta cell maturity. These findings raise the possibility that changes in Rfx6 expression or activity may contribute to beta cell failure in man.

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