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Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon (16S rNA-seq)

ABSTRACT: Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon (16S rNA-seq)

PROVIDER: PRJNA550526 | ENA |

REPOSITORIES: ENA

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Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon (RNA-seq)

Project description:The colon contains a dense metabolically potent microbiota. The colonic O-glycan-rich mucus has been recognized as a key barrier to prevent microbial intrusion, but how this system forms and functions remains unclear. Here, we discovered that the colon mucus is mainly forged by microbiota-dependent secretion of O-glycosylated Muc2 by goblet cells in the ascending colon, where it seamlessly encapsulates the fecal materials including the microbiota. Deletion of O-glycans in the ascending colon impaired the segregating function of the mucous coating, leading to altered structure and metabolic output of the microbiota, and transcriptional homeostasis of the entire host mucosa. These findings represent a paradigm change of the prevailing model of the colon mucus system and provides new insights into host and microbiota symbiosis.

2020-10-28 | GSE133174 | GEO

Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon (16S rNA-seq)

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Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon

Project description:Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon

| PRJNA550524 | ENA

Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon (RNA-seq)

Project description:Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon (RNA-seq)

| PRJNA550137 | ENA

Ascending colon-derived mucin-type O-glycans form key mucus layers encapsulating microbiota in the colon

Project description:This SuperSeries is composed of the SubSeries listed below.

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Transcriptomic profiles of Streptococcus mutans UA159 grown in the presence or absence of mucins or mucin glycans

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Transcriptomic profiles of Candida albicans grown in the presence or absence of mucin glycans

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Transcription profiling of human normal mucosa, cecum, ascending, transverse, sigmoid and rectum

Project description:Normal human colorectal mucosa was sampled at points along the colon. Experiment Overall Design: Normal human colorectal mucosa, cecum, ascending, transverse, sigmoid and rectum

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Transcriptomic profiles of Pseudomonas aeruginosa PAO1 grown in the presence or absence of mucins or mucin-glycans

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Transcriptomic profiles of Pseudomonas aeruginosa PA14 grown in the presence or absence of mucins or mucin-glycans

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