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Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE)

ABSTRACT: Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE)

PROVIDER: PRJNA551513 | ENA |

REPOSITORIES: ENA

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Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE)

Project description:Studies of a Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE)

| PRJNA551512 | ENA

Transcription profiling time series of human skeletal muscle samples from metabolic syndrome patients following defined exercise (STRRIDE study)

Project description:STRRIDE is an exercise intervention study of different doses and intensities in overweight women and men with the metabolic syndrome. We profiled biopsies from 3 female and 3 male STRRIDE subjects in the âhighâ exercise group (2,200 kCal/wk). Muscle biopsies were profiled at entry (0h), and after 9 months of aerobic training (24 hrs post-last bout, 96 hrs post last bout, and 336h (14 days) de-training). Included also are pilot expression data from 3 male subjects.<br><br>Note that files GSM19162.txt and GSM20659.txt as downloaded from GEO are identical.

2007-08-02 | E-GEOD-1295 | biostudies-arrayexpress

Analysis of aerobic and resistance training-induced changes in human vastus lateralis gene expression

Project description:The purpose of this study was to use global gene expression to identify skeletal muscle genes that correlate with exercise-induced Si changes. Longitudinal cohorts from the Studies of Targeted Risk Reduction Intervention through Defined Exercise (STRRIDE) were utilized for vastus lateralis gene expression profiles. Si was determined via intravenous glucose tolerance test pre- and post-training. Pearson product-moment correlation coefficients determined relationships between a) baseline and b) training-induced changes in gene expression and Si after training.

2016-06-30 | GSE83352 | GEO

Analysis of aerobic and resistance training-induced changes in human vastus lateralis gene expression

2016-06-30 | E-GEOD-83352 | biostudies-arrayexpress

STRRIDE Study

Project description:STRRIDE is an exercise intervention study of different doses and intensities in overweight women and men with the metabolic syndrome. We profiled biopsies from 3 female and 3 male STRRIDE subjects in the “high” exercise group (2,200 kCal/wk). Muscle biopsies were profiled at entry (0h), and after 9 months of aerobic training (24 hrs post-last bout, 96 hrs post last bout, and 336h (14 days) de-training). Included also are pilot expression data from 3 male subjects. Keywords: other

2004-04-08 | GSE1295 | GEO

Effects of Exercise on Cardiovascular Health (STRRIDE)

Project description:<p>The STRRIDE study is the combination of three interventional trials to evaluate dose and intensity of physical activity on cardiometabolic health. The three component studies are <a href="https://clinicaltrials.gov/ct2/show/NCT00200993?term=NCT00200993&draw=2&rank=1" target="_blank"> Peripheral Effects of Exercise on Cardiovascular Health (STRRIDE I, ClinicalTrials.gov Identifier: NCT00200993)</a>, <a href="https://clinicaltrials.gov/ct2/show/NCT00275145?term=NCT00275145&draw=2&rank=1" target="_blank"> Effects of Resistence and Aerobic Exercise on Cardiovascular Health (STRRIDE II, ClinicalTrials.gov Identifier: NCT00275145)</a> and <a href="https://clinicaltrials.gov/ct2/show/NCT00962962?term=NCT00962962&draw=2&rank=1" target="_blank"> Exercise Dose-Response Effects in Prediabetes (STRRIDE-PD, ClinicalTrials.gov Identifier: NCT00962962)</a>.</p>

| phs001855 | dbGaP

Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention

Project description:The participants performed an 8-week supervised aerobic endurance exercise intervention program. Biopsies of both adipose tissue and skeletal muscle were collected at associated timepoints and a matched analysis was performed.

2023-08-09 | GSE161749 | GEO

Acute and long-term exercise adaptation of adipose tissue and skeletal muscle in humans: a matched transcriptomics approach after 8-week training-intervention

2023-08-09 | GSE161750 | GEO

High and low exercise responders

Project description:Aerobic exercise capacity is a strong predictor of disease and survivability but the utility of exercise intervention is largely dependent on how one’s genome interacts with an exercise-training environment. A newly developed rat model selectively bred for inherited differences in response to aerobic exercise training shows to be a useful resource to sort out the networks of genes responsible for signalling exercise-induced changes that benefit cardiac function.

2012-01-01 | GSE20997 | GEO

Voluntary exercise suppresses tumor growth through exercise-directed recruitment and intratumoral infiltration of NK cells

Project description:Voluntary exercise reduces the risk of cancer and lowers the risk of disease recurrence. Yet the mechanisms for this protection remain to be elucidated. Here we demonstrate that exercise halves tumor growth through an exercise-dependent mobilization and intratumoral infiltration of NK cells in malignant melanoma. Using voluntary wheel running, we show that exercise prior to and during B16 tumor challenge reduced tumor growth by 67%, and this reduction was associated with increased inflammation and immune cell infiltrates, especially NK cells, in the tumors from exercising mice. Depletion of NK cells blunted the exercise-dependent reduction in tumor growth. Moreover, during exercise, NK cells were engaged through an epinephrine-dependent mobilization to the circulation and redistributed to peripheral tissues through an IL-6 dependent mechanism. This study highlights the importance of exercise-dependent immune regulation in the control of malignant melanoma Gene expression profile of melanoma tumor tissue from two groups of exercise and non-exercise mice

2016-07-21 | E-GEOD-62628 | biostudies-arrayexpress

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