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Sex-specific programming effects of parental obesity in pre-implantation embryonic development

ABSTRACT: Sex-specific programming effects of parental obesity in pre-implantation embryonic development

PROVIDER: PRJNA553000 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9649770.fastq.gz	Fastqsanger.gz
	SRR9649780.fastq.gz	Fastqsanger.gz
	SRR9649761.fastq.gz	Fastqsanger.gz
	SRR9649771.fastq.gz	Fastqsanger.gz
	SRR9649781.fastq.gz	Fastqsanger.gz

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Oocytes]

Project description:Obesity is a global rising problem with epidemiological dimension. Obese parents can have programming effects on their offspring leading to obesity and associated diseases in later life. This constitutes a vicious circle. Epidemiological data and studies in rodents demonstrated differential programming effects in male and female offspring, but the timing of their developmental origin is not known. This study investigated if sex-specific programming effects of parental obesity can already be detected in the pre-implantation period. Diet induced obese male or female mice were mated with normal-weight partners and blastocysts were recovered. Gene expression profiling revealed sex-specific responses of the blastocyst transcriptome to maternal and paternal obesity. The changes in the transcriptome of male blastocysts were more pronounced than those of female blastocysts, with a stronger impact of paternal than of maternal obesity. The sperm of obese mice revealed an increased abundance of several miRNAs compared to lean mice. Our study indicates that sex-specific programming effects of parental obesity already start in the pre‑implantation period and reveals specific alterations of the sperm miRNA profile as mechanistic link to programming effects of paternal obesity.

2019-07-07 | GSE133914 | GEO

Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development_Microarray data on blastocyst transcriptomes

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Oocytes]

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Oocytes]

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development [RNASeq Data of Sperm]

| PRJNA553001 | ENA

Sex-specific programming effects of parental obesity in pre-implantation embryonic development_Microarray data on blastocyst transcriptomes

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development_Microarray data on blastocyst transcriptomes

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small RNA reads sperm parental obesity

Project description:Sex-specific programming effects of parental obesity in pre-implantation embryonic development_small RNASeq Data of Sperm

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Sex-specific programming effects of parental obesity in pre-implantation embryonic development

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-07-07 | GSE133916 | GEO

Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain

Project description:Prenatal alcohol exposure is recognized to alter DNA methylation profiles of brain cells during development, and as being part of the molecular basis underpinning Fetal Alcohol Spectrum Disorder (FASD) etiology. However, we have negligible information on the effects of alcohol during the initial embryonic stages, a window marked with dynamic DNA methylation reprogramming, and on how this may rework the brain developmental program. Using a pre-clinical in vivo mouse model, we show that pre-implantation alcohol exposure leads to adverse developmental outcomes that replicate clinical facets observed in children with FASD. Genome-wide DNA methylation analyses of fetal forebrains uncovered sex-specific alterations, including partial loss of DNA methylation maintenance at imprinted control regions, and abnormal re-establishment of de novo DNA methylation profiles in various biological pathways (e.g, neural/brain development). These findings support the contribution of alcohol-induced DNA methylation programming deviations during pre-implantation to the manifestations of neurodevelopmental phenotypes associated with FASD.

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Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain

Project description:Pre-implantation alcohol exposure induces lasting sex-specific DNA methylation programming errors in the developing forebrain

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