Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

ABSTRACT: Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

PROVIDER: PRJNA554101 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9671010.fastq.gz	Fastqsanger.gz
	SRR9671011.fastq.gz	Fastqsanger.gz
	SRR9671012.fastq.gz	Fastqsanger.gz
	SRR9671013.fastq.gz	Fastqsanger.gz
	SRR9671014.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses.

Project description:Follicular regulatory T (TFR) cells have specialized roles in modulating follicular helper T (TFH) cell activation of B cells. However, the precise role of TFR cells in controlling antibody responses to foreign antigens and autoantigens in vivo is still unclear due to a lack of specific tools. A TFR cell-deleter mouse was developed that selectively deletes TFR cells, facilitating temporal studies. TFR cells were found to regulate early, but not late, germinal center (GC) responses to control antigen-specific antibody and B cell memory. Deletion of TFR cells also resulted in increased self-reactive immunoglobulin (Ig) G and IgE. The increased IgE levels led us to interrogate the role of TFR cells in house dust mite models. TFR cells were found to control TFH13 cell-induced IgE. In vivo, loss of TFR cells increased house-dust-mite-specific IgE and lung inflammation. Thus, TFR cells control IgG and IgE responses to vaccines, allergens and autoantigens, and exert critical immunoregulatory functions before GC formation.

| S-EPMC6754271 | biostudies-literature

Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity

Project description:Long-lived T follicular helper cells retain plasticity and help sustain humoral immunity

| PRJNA578723 | ENA

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

Project description:Tfh and Tfr cells from OVA or HDM challenged mice

2019-09-02 | GSE134153 | GEO

Store-operated Ca2+ entry in follicular T cells controls humoral immune responses and autoimmunity

Project description:T follicular helper (TFH) cells promote affinity maturation of B cells in germinal centers (GCs), whereas T follicular regulatory (TFR) cells limit GC reaction. Store-operated Ca2+ entry (SOCE) through Ca2+ release-activated Ca2+ (CRAC) channels mediated by STIM and ORAI proteins is a fundamental signaling pathway in T lymphocytes. Here we show that SOCE is required for the differentiation and function of both TFH and TFR cells. Conditional deletion of Stim1 and Stim2 genes in T cells or Treg cells results in spontaneous autoantibody production and humoral autoimmunity. Conversely, antibody-mediated immune responses following viral infection critically depend on SOCE in TFH cells. Mechanistically, STIM1 and STIM2 control early TFR and TFH cell differentiation through NFAT-mediated IRF4, BATF and Bcl-6 expression. SOCE plays a dual role in GC response by controlling TFH and TFR cell function, thus enabling protective B cell responses and preventing humoral autoimmunity. RNAseq analyses of WT and Stim1Stim2 DKO follicular T cells and non-follicular T cells; 4-6 mice per cohort in duplicates. Mice were infected for 10 days with LCMV.

2016-03-10 | E-GEOD-79039 | biostudies-arrayexpress

Metabolic control of Tfh and humoral immunity by phosphatidylethanolamine

Project description:Cytidine diphosphate (CDP)-ethanolamine pathway of phospholipid metabolism coordinates metabolic programming of Tfh cell responses and humoral immunity.

2021-05-26 | GSE147190 | GEO

Store-operated Ca2+ entry in follicular T cells controls humoral immune responses and autoimmunity

2016-03-10 | GSE79039 | GEO

Stearoyl-CoA desaturase mediated monounsaturated fatty acid availability supports humoral immunity

Project description:Immune cells can metabolize fatty acids (FAs) to generate energy. The source of different fatty acid species, and their impacts on humoral immunity remains poorly understood. Here we report that proliferating B cells require increased amount of monounsaturated fatty acids (MUFA) to maintain mitochondrial metabolism and mTOR activity, and to prevent excessive autophagy and endoplasmic reticular (ER) stress. Furthermore, B cell extrinsic Stearoyl-Coa desaturase (SCD) activity generates endogenous MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.

2020-12-02 | GSE162460 | GEO

Role of activated PI3K-delta signaling in humoral immunity

Project description:Role of activated PI3K-delta signaling in humoral immunity

| PRJNA720927 | ENA

Metabolic control of Tfh and humoral immunity by phosphatidylethanolamine

Project description:Metabolic control of Tfh and humoral immunity by phosphatidylethanolamine

| PRJNA613290 | ENA

Venous plexus-associated lymphoid hubs support meningeal humoral immunity

Project description:Venous plexus-associated lymphoid hubs support meningeal humoral immunity

| PRJNA1064095 | ENA