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Acinetobacter baumannii

ABSTRACT: Carbapenem Resistant Acinetobacter baumannii harboring the OXA-24/40-like resistance mechanism OXA-72

PROVIDER: PRJNA554907 | ENA |

REPOSITORIES: ENA

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			Action	DRS
		Other
	SRR11096100_1.fastq.gz	Fastqsanger.gz
	SRR11096100_2.fastq.gz	Fastqsanger.gz
	SRR11096101_1.fastq.gz	Fastqsanger.gz
	SRR11096101_2.fastq.gz	Fastqsanger.gz

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Similar Datasets

Project description:Carbapenem Resistant Acinetobacter baumannii harboring the OXA-24/40-like resistance mechanism OXA-72 finished assemblies

| PRJNA557486 | ENA

Transcriptional changes in response to OXA-23 overexpression in Acinetobacter baumannii ATCC 17978

Project description:Purpose: The goal of this study was to elucidate the collateral effects associated with OXA-23 overexpression on the Acinetobacter baumannii global transcriptome. Results: Besides the 99.73-fold increase in blaOXA-23 transcript upon IPTG induction, no other transcripts showed more than a 2-fold change compared to the wildtype control. This suggests that OXA-23 over expression to levels similarly observed in multi drug resistant A. baumannii clinical isolates does not effect the transcriptome.

2021-11-15 | GSE185203 | GEO

Host cell response after infection with a virulent and a non virulent Acinetobacter baumannii IC2 OXA-23 strain

Project description:Acinetobacter baumannii is an emerging nosocomial pathogen that causes severe infections such as pneumonia or blood stream infections. As the incidence of multidrug-resistant A. baumannii infections in intensive care units increases, the pathogen is considered of greater clinical concern. Little is known about the molecular interaction of A. baumannii with its host yet. In order to study the host cell response upon A. baumannii infection, a complexome analysis was performed. For this, we identified a virulent ( A. baumannii 2778) and a non virulent (A. baumannii 1372) clinical isolate of genetic similarity > 95 % (both isolates from IC 2 harboring OXA 23). HUVECs were infected with each strain and enriched mitochondrial fraction was used for complexome profiling. Complexome analysis identified dramatic reduction of mitochondrial protein complexes in the strain of greater virulence.

2023-04-10 | PXD035235 | Pride

Comparison of the gene expression profiles of different strains of A. baumannii by microarrays

Project description:In the present work we compare the gene expression profile of A. baumannii and a mutant knock-out strain of A. baumannii lacking a small RNA gene 13573 and the corresponding small RNA 13573 over-producing strain. The main objective is to recognize the main pathways in which the small RNA 13573 is involved. Moreover, the same wild type strain was used to infect mice and was further analyzed after the infection with the aim of finding genes differentially expressed in vivo. Three biological replicates have been performed for each comparison. The RNA collection from Acinetobacter baumannii strain over-expresing the small RNA (sample 13573) was compared with this isolated from A. baumannii harboring the empty vector (PETRA sample) while gene expression in the knock-out strain (KO sample) was compared with the wild type strain Acinetobacter baumannii ATCC 17978 (ATCC sample). The RNA from A.baumannii recovered from the infected animals (INF sample) was compared with the wild type (ATCC).

2016-08-01 | E-GEOD-60348 | biostudies-arrayexpress

A. baumannii Cells: oleanolic acid (OA) tretment vs. ethanol treatment (OA solvent)

Project description:Transcriptional profiling of Acinetobacter baumannii ATCC17978 cells comparing treated ethanol cells with oleanolic acid treated. Based on the gene expression, we performed experiments to confirm the therapeutic effect and mechanism of OA in A. baumannii. We performed a transcriptome anaylsis of 2 samples that are OA and ethanol treatment, respectively.

2014-08-09 | E-GEOD-60239 | biostudies-arrayexpress

A. baumannii Cells: oleanolic acid (OA) tretment vs. ethanol treatment (OA solvent)

2014-08-09 | GSE60239 | GEO

RNA-Seq of Benzalkonium Chloride Treated and Untreated Acinetobacter baumannii

Project description:The goal of this RNA-Seq study was to determine Acinetobacter baumannii's transcriptiional response to sub-MIC concentrations of benzalkonium chloride in Acinetobacter baumannii. This RNA-seq data was then utilized to aide in the determination of the sub-MIC mechanism of action for benzalkonium chloride.

2018-01-23 | GSE96746 | GEO

Relationship between tolerance and persistence mechanisms in Acinetobacter baumannii strains with AbkAB Toxin-Antitoxin system

Project description:Unknown are the mechanisms of tolerance and persistence associated to several compounds in A.baumannii clinical isolates. Using transcriptomical and microbiological studies, we found a link between bacterial tolerance mechanisms to clorhexidine as well as the development of persistence in presence of imipenem in an A.baumannii strain belonging to ST-2 clinical clone (carbapenem-resistant with OXA-24 ß-lactamase and AbkAB TA system by plasmid). Interestingly, in A.baumannii ATCC17978 strain (carbapenem-susceptible isolate which carries AbkAB TA system by plasmid) showed persistence in presence of imipenem.

2018-02-09 | GSE110207 | GEO

Project description:OXA-72 producing Acinetobacter baumannii

| PRJNA492390 | ENA

Multi-omics approach to study global changes in a triclosan mutant strain of Acinetobacter baumannii ATCC 17978.

Project description:Acinetobacter baumannii AB042, a triclosan-resistant mutant, was examined for modulated gene expression using whole genome sequencing, transcriptomics, and proteomics in order to understand the mechanism of triclosan-resistance as well as its impact on A. Baumannii.

2016-09-28 | GSE87398 | GEO

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