Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [OCT4OFF SOX2OFF ATAC-seq]

ABSTRACT: Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [OCT4OFF SOX2OFF ATAC-seq]

PROVIDER: PRJNA556019 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9732190_1.fastq.gz	Fastqsanger.gz
	SRR9732190_2.fastq.gz	Fastqsanger.gz
	SRR9732200_1.fastq.gz	Fastqsanger.gz
	SRR9732200_2.fastq.gz	Fastqsanger.gz
	SRR9732191_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

Project description:Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle

| PRJNA556148 | ENA

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [MD-OCT4 ATAC-seq]

Project description:Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [MD-OCT4 ATAC-seq]

| PRJNA556025 | ENA

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [MD-OCT4 ChIP-seq]

Project description:Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [MD-OCT4 ChIP-seq]

| PRJNA556314 | ENA

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [OCT4OFF SOX2OFF ChIP-seq]

Project description:Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [OCT4OFF SOX2OFF ChIP-seq]

| PRJNA556023 | ENA

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [OCT4-AID ATAC-seq]

Project description:Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [OCT4-AID ATAC-seq]

| PRJNA556315 | ENA

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [MD-OCT4 ChIP-seq]

Project description:The pioneer activity of transcription factors allows for opening of inaccessible regulatory elements and has been extensively studied in the context of cellular differentiation and reprogramming. In contrast, the function of pioneer activity in self-renewing cell divisions and across the cell cycle is poorly understood. Here we assessed the interplay between OCT4 and SOX2 in controlling chromatin accessibility of mouse embryonic stem cells. We found that OCT4 and SOX2 operate in a largely independent manner even at co-occupied sites, and that their cooperative binding is mostly mediated indirectly through regulation of chromatin accessibility. Controlled protein degradation strategies revealed that the uninterrupted presence of OCT4 is required for post-mitotic re-establishment and interphase maintenance of chromatin accessibility, and that highly OCT4-bound enhancers are particularly vulnerable to transient loss of OCT4 expression. Our study sheds light on the constant pioneer activity required to maintain the dynamic pluripotency regulatory landscape in an accessible state.

2019-11-26 | GSE134674 | GEO

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [MD-OCT4 ATAC-seq]

2019-11-26 | GSE134673 | GEO

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [OCT4OFF SOX2OFF ChIP-seq]

2019-11-26 | GSE134669 | GEO

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [OCT4OFF SOX2OFF ATAC-seq]

2019-11-26 | GSE134652 | GEO

Dynamic regulation of chromatin accessibility by pluripotency transcription factors across the cell cycle [OCT4-AID ATAC-seq]

2019-11-26 | GSE134675 | GEO