Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dynamic changes of muscle insulin sensitivity after metabolic surgery III

ABSTRACT: Dynamic changes of muscle insulin sensitivity after metabolic surgery III

PROVIDER: PRJNA557237 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Dynamic changes of muscle insulin sensitivity after metabolic surgery III

Project description:The mechanisms underlying improved insulin sensitivity after surgically-induced weight loss are still unclear. We monitored skeletal muscle metabolism in obese individuals before and over 52 weeks after metabolic surgery. Initial weight loss occurs in parallel with a decrease in muscle oxidative capacity and respiratory control ratio. Persistent elevation of intramyocellular lipid intermediates, likely resulting from unrestrained adipose tissue lipolysis, accompanies the lack of rapid changes in insulin sensitivity. Simultaneously, alterations in skeletal muscle expression of genes involved in calcium/lipid metabolism and mitochondrial function associate with subsequent distinct DNA methylation patterns at 52 weeks after surgery. Thus, initial unfavorable metabolic changes including insulin resistance of adipose tissue and skeletal muscle precede epigenetic modifications of genes involved in muscle energy metabolism and the long-term improvement of insulin sensitivity.

2019-08-14 | GSE134957 | GEO

Dynamic changes of muscle insulin sensitivity after metabolic surgery

Project description:Dynamic changes of muscle insulin sensitivity after metabolic surgery

| PRJNA557248 | ENA

Dynamic changes of muscle insulin sensitivity after metabolic surgery I

Project description:Dynamic changes of muscle insulin sensitivity after metabolic surgery I

| PRJNA557234 | ENA

Dynamic changes of muscle insulin sensitivity after metabolic surgery IV

Project description:Dynamic changes of muscle insulin sensitivity after metabolic surgery IV

| PRJNA557249 | ENA

Dynamic changes of muscle insulin sensitivity after metabolic surgery II

Project description:Dynamic changes of muscle insulin sensitivity after metabolic surgery II

| PRJNA557236 | ENA

Dynamic changes of muscle insulin sensitivity after metabolic surgery IV

2019-08-14 | GSE135063 | GEO

Dynamic changes of muscle insulin sensitivity after metabolic surgery II

2019-08-14 | GSE134956 | GEO

Dynamic changes of muscle insulin sensitivity after metabolic surgery I

2019-08-14 | GSE134913 | GEO

Effects of exercise training on skeletal muscle insulin sensitivity in obesity patients undergoing RYGB surgery: a randomized controlled trial

Project description:We reported that skeletal muscle insulin sensitivity was restored to a lean phenotype with exercise training in patients undergoing RYGB surgery. For that, the goals of this study is to identify changes in the skeletal muscle transcriptome profiling (RNA-seq) that could explain the insulin sensitivity improvement of RYGB + exercise training group.

2020-05-19 | GSE137631 | GEO

Reduced circulating insulin enhances insulin sensitivity in old mice and extends lifespan

Project description:The causal relationships between insulin levels, insulin resistance, and longevity are not fully elucidated. Genetic down-regulation of insulin/insulin-like growth factor 1 (Igf1) signaling components can extend invertebrate and mammalian lifespan, but insulin resistance, a natural form of decreased insulin signaling, is associated with greater risk of age-related disease in mammals. We compared Ins2+/- mice to Ins2+/+ littermate controls, on a genetically stable Ins1-null background. Proteomic and transcriptomic analyses of livers from 25 week-old mice suggested potential for healthier aging and altered insulin sensitivity in Ins2+/- mice. Halving Ins2 lowered circulating insulin by 25-34% in aged female mice, without altering Igf1 or circulating Igf1. Remarkably, decreased insulin led to lower fasting glucose and improved insulin sensitivity in aged mice. Moreover, lowered insulin caused significant lifespan extension, observed across two diverse diets. Our study indicates that elevated insulin contributes to age-dependent insulin resistance, and that limiting basal insulin levels can extend lifespan.

2017-05-31 | GSE99440 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data