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Temporal profile of brain gene expression associated with learning in an anuran amphibian

ABSTRACT: Temporal profile of brain gene expression associated with learning in an anuran amphibian

PROVIDER: PRJNA557243 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9856780_1.fastq.gz	Fastqsanger.gz
	SRR9856780_2.fastq.gz	Fastqsanger.gz
	SRR9856781_1.fastq.gz	Fastqsanger.gz
	SRR9856781_2.fastq.gz	Fastqsanger.gz
	SRR9856782_1.fastq.gz	Fastqsanger.gz

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Temporal profile of brain gene expression associated with learning in an anuran amphibian

Project description:Reported here are the transcriptomic changes resulting from learning, in the brain of an anuran amphibian. RNA sequencing was utilized to investigate temporal gene expression patterns resulting from conditioned learning in the fire-bellied toad, Bombina orientalis. As a basal tetrapod lineage, B. orientalis represents a robust candidate for investigating the evolution of molecular mechanisms underlying learning in vertebrates. Differential expression following learning reveled activity in molecular pathways related to immediate early gene expression, cytoskeletal modification, axon guidance activity, and apoptotic processes. Learning in the fire-bellied toad is characterized by early IEG activity coinciding with transcriptional activity and structural modification, followed by axon guidance and adhesion activity, and late neural pruning.

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Temporal profile of brain gene expression associated with learning in an anuran amphibian II

Project description:Reported here are the transcriptomic changes resulting from extinction learning, in the brain of an anuran amphibian. RNA sequencing was utilized to investigate gene expression patterns resulting from conditioned learning in the fire-bellied toad, Bombina orientalis. As a basal tetrapod lineage, B. orientalis represents a robust candidate for investigating the evolution of molecular mechanisms underlying learning in vertebrates. The gene expression patterns associated with extinction learning in this species shared similarities with to those found in mammals submitted to extinction, but interesting divergent profiles highlighted potential differences in the mechanisms of learning and memory among tetrapods.

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Temporal profile of brain gene expression associated with learning in an anuran amphibian II

Project description:Temporal profile of brain gene expression associated with learning in an anuran amphibian II

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Temporal Profile of Brain Gene Expression After Prey Catching Conditioning in an Anuran Amphibian.

Project description:A key goal in modern neurobiology is to understand the mechanisms underlying learning and memory. To that end, it is essential to identify the patterns of gene expression and the temporal sequence of molecular events associated with learning and memory processes. It is also important to ascertain if and how these molecular events vary between organisms. In vertebrates, learning and memory processes are characterized by distinct phases of molecular activity involving gene transcription, structural change, and long-term maintenance of such structural change in the nervous system. Utilizing next generation sequencing techniques, we profiled the temporal expression patterns of genes in the brain of the fire-bellied toad Bombina orientalis after prey catching conditioning. The fire-bellied toad is a basal tetrapod whose neural architecture and molecular pathways may help us understand the ancestral state of learning and memory mechanisms in tetrapods. Differential gene expression following conditioning revealed activity in molecular pathways related to immediate early genes (IEG), cytoskeletal modification, axon guidance activity, and apoptotic processes. Conditioning induced early IEG activity coinciding with transcriptional activity and neuron structural modification, followed by axon guidance and cell adhesion activity, and late neuronal pruning. While some of these gene expression patterns are similar to those found in mammals submitted to conditioning, some interesting divergent expression profiles were seen, and differential expression of some well-known learning-related mammalian genes is missing altogether. These results highlight the importance of using a comparative approach in the study of the mechanisms of leaning and memory and provide molecular resources for a novel vertebrate model in the relatively poorly studied Amphibia.

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