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ABSTRACT: Adineta vaga L1 PacBio

PROVIDER: PRJNA558051 | ENA |

REPOSITORIES: ENA

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Dataset's files

Source:

			Action	DRS
	SRR9886612_subreads.fastq.gz	Fastqsanger.gz
	SRR9900840_subreads.fastq.gz	Fastqsanger.gz
	SRR9900841_subreads.fastq.gz	Fastqsanger.gz
	SRR9900832_subreads.fastq.gz	Fastqsanger.gz
	SRR9900842_subreads.fastq.gz	Fastqsanger.gz

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Horizontal acquisition of a DNA ligase improves DNA damage tolerance in eukaryotes

Project description:Bdelloid rotifers are part of the restricted circle of multicellular animals that can withstand a wide range of genotoxic stresses at any stage of their life cycle. In this study, bdelloid rotifer Adineta vaga was used as a model to decipher the molecular basis of their extreme tolerance. Proteomic analysis showed that a specific DNA ligase, different from those usually involved in DNA repair in eukaryotes, is strongly over-represented upon ionizing radiation. A phylogenetic analysis revealed its orthology to prokaryotic DNA ligase E, and its horizontal acquisition by bdelloid rotifers and plausibly other eukaryotes. The fungus Mortierella verticillata, having a single copy of this DNA Ligase E homolog, also exhibits an increased radiation tolerance with an over-expression of this DNA ligase E following X-ray exposure. We also provide evidence that A. vaga ligase E is a major contributor of DNA breaks ligation activity, which is a common step of all important DNA repair pathways. Consistently, its heterologous expression in human cell lines significantly improved their radio-tolerance. Overall, this study highlights the potential of horizontal gene transfers in eukaryotes, and their contribution to the adaptation to extreme conditions.

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