Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis [RNA-seq]

ABSTRACT: Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis [RNA-seq]

PROVIDER: PRJNA558250 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9888130_1.fastq.gz	Fastqsanger.gz
	SRR9888130_2.fastq.gz	Fastqsanger.gz
	SRR9888140_1.fastq.gz	Fastqsanger.gz
	SRR9888140_2.fastq.gz	Fastqsanger.gz
	SRR9888131_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 28

Similar Datasets

Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis

Project description:Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis

| PRJNA558245 | ENA

Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis [ATAC-seq]

Project description:Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis [ATAC-seq]

| PRJNA558249 | ENA

Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis [RNA-seq]

Project description:BACKGROUND/ AIMS: Severe forms of alcoholic liver disease are associated with increased susceptibility to infections largely due to immune dysfunction. In this study, we analyze the phenotypic, molecular and functional profiles of the mononuclear phagocyte system of patients with cirrhosis, severe alcoholic hepatitis (sAH) or acute-on-chronic liver failure (ACLF). RESULTS: sAH and ACLF patients display a severe impairment of the TH1-promoting IL-12p70/IFNgamma/CXCL10 axis. Furthermore, the CD14+ monocytes and classical dendritic cells of these patients are unable to mount an appropriate pro-inflammatory response after stimulation with PAMPs associated with gram-negative bacteria or fungal pathogens. These cells also have reduced polyfunctionality, which is associated with a higher risk of subsequent infection. Finally, we show that CD14+ monocytes of sAH and ACLF patients display a similar transcriptional profile characterized by immunosuppressive features. This was accompanied with changes in chromatin accessibility in enhancer regions of key immune and metabolic genes. CONCLUSIONS: Altered transcriptional program and functional properties of monocytes from sAH and ACLF patients has strong epigenetic determinants.

2020-08-02 | GSE135285 | GEO

Epigenetic basis for monocyte dysfunction in acute-on-chronic liver failure and alcoholic hepatitis [ATAC-seq]

2020-08-02 | GSE135284 | GEO

Pathogenesis of alcoholic hepatitis

Project description:Pathogenesis of alcoholic hepatitis

| PRJNA704267 | ENA

Hepatic cell proliferation and outcome in alcoholic hepatitis: histology, gene expression and effect of stem cell therapy

Project description:Regeneration and alcoholic hepatitis

2014-08-31 | E-MTAB-2664 | biostudies-arrayexpress

Plasma Protein Signatures in Alcoholic Hepatitis

Project description:Supporting plasma proteomic data from clinical patients with alcoholic hepatitis in comparison to relevant controls and across treatment time points, baseline, 28/29 days, 12 weeks. Samples were digested with trypsin, labeled with TMT 10-Plex, then analyzed by LC-MS/MS. Data was searched with MS-GF+ using PNNL's DMS Processing pipeline.

2019-11-01 | MSV000084528 | MassIVE

Silent Alcoholic Steatohepatitis vs Alcoholic Hepatitis: Clinical, Histological and Transcriptome Analysis

Project description:Silent Alcoholic Steatohepatitis vs Alcoholic Hepatitis: Clinical, Histological and Transcriptome Analysis

| PRJNA635585 | ENA

INTEAM CONSORTIUM - ALCOHOLIC HEPATITIS LIVER RNA SEQUENCING

Project description:INTEAM CONSORTIUM - ALCOHOLIC HEPATITIS LIVER RNA SEQUENCING

| PRJNA531222 | ENA

INTEAM CONSORTIUM - ALCOHOLIC HEPATITIS LIVER RNA SEQUENCING

Project description:INTEAM CONSORTIUM - ALCOHOLIC HEPATITIS LIVER RNA SEQUENCING

| PRJNA531223 | ENA