Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

CircRNA sequencing facilitates quantitative analysis of CUS mice hippocampus and Control mice hippocampus

ABSTRACT: circRNA sequencing facilitates quantitative analysis of CUS mice hippocampus and Control mice hippocampus

PROVIDER: PRJNA558498 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

circRNA sequencing facilitates quantitative analysis of CUS mice hippocampus and Control mice hippocampus

Project description:The goal of this study is to seek the potential circular RNAs (circRNAs), which express differently between control group and chronic unpredictable stress (CUS) group mouse hippocampus, involved in major dipresssion disorder (MDD) by high-throughput sequencing. QPCR was preformed to identify the circRNAs trend. CircRNAs are a class of RNAs in the eukaryotic transcriptome. The function and explicit downstream mechanisms of circRNA regulated in maior depression disorser remain unclear. To further investigate the potential role of circRNAs in MDD, we performed human and mouse homology screening on circRNA sequences using the Basic Local Alignment Search Tool on the NCBI website. CircSTAG1, a homologous human and mouse circRNA, was found downregulated in circRNA high-throughput sequencing. Our study represents the first detailed analysis of circRNA expressing differently in CUS mouse hippocampus by high-throughput sequencing.

2022-08-02 | GSE135343 | GEO

The expression profiles of circRNAs in hippocampus from mice with prenatal glyphosate exposure

Project description:In this study, the circRNAs expression pattern in hippocampus of postnatal day (PND) 28 mice offsprings which were exposured by glyphosate-based herbicide (GBH) during pregnancy and lactation was investigated. CircRNA microarray had detected 330 upregulated and 333 downregulated miRNAs in the PND28 mice offsprings' hippocampus

2018-03-13 | GSE111670 | GEO

Identification and characterization analysis of the different genes in CUS mouse treated with RVG-circDYM-EVs using RNA-seq.

Project description:Whole RNA-sequencing analysis was performed and analyzed by Lc. Biotech Co. Ltd. (Hangzhou, China). hippocampus tissue from the Ctrl + Ctrl group, Ctrl + circDYM group, CUS + Ctrl group, and CUS + circDYM group were collected in TRIzol. Total RNAs were extracted from Trizol. UMI technology was used to label each sequence fragment with sequence tags, which minimized the interference of duplication caused by PCR amplification on the quantitative accuracy of the transcriptome. RNA sequencing reads were aligned to the mouse genome (GRCh37/hg19) using the software Hisat2 (2.0.4). Transcript abundance was evaluated by calculating fragments per kilo base of exon per million fragments mapped (FPKM).

2023-11-11 | GSE189273 | GEO

Total RNA sequencing in the hippocampus of wild type and APP/PS1 mice

Project description:Our study aimed to dissect differentially expressed circRNAs in the hippocampus of wild type and APP/PS1 mice and demonstrated the important role of circRNA in Alzheimer's disease.

2020-10-05 | GSE158995 | GEO

Whole-transcriptomic analysis of circRNA-miRNA-mRNA ceRNA network in 4-month APP/PS1 mouse hippocampus

Project description:Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and the molecular mechanisms of AD remain unclear. Accumulating evidence indicates the involvement of non-coding RNAs in AD pathogenesis. Here, we applied RNA-seq to explore the expression changes of circRNA, miRNA, and mRNA simultaneously, and investigate competing endogenous RNA (ceRNA) networks in hippocampus of 4-month APP/PS1 and wild-type mice.

2022-07-27 | GSE166393 | GEO

circRNA Microarray analysis of hippocampus from mouse treated by HFD

Project description:circRNA Microarray analysis of hippocampus from mouse treated by HFD

| PRJNA859511 | ENA

LncRNA and circRNA expression profiles of Aβ25-35-induced AD mice hippocampus treated with Tripterygium Glycoside

Project description:LncRNA and circRNA expression profiles of Aβ25-35-induced AD mice hippocampus treated with Tripterygium Glycoside

| PRJNA842389 | ENA

Enterobacteria phage CUS-3

Project description:Integrated prophage CUS-3 from Escherichia coli RS218

| PRJNA19411 | ENA

Next Generation Sequencing Facilitates Quantitative Analysis of hippocampus transcriptomes from WT and miR-301a-/- mice

Project description:Purpose: we used next generation sequencing to analyze gene expression profiles of hippocampus from WT and miR-301a-/- mice. The goals of this study are to compare the different gene expression profiles of hippocampus between WT and miR-301a-/- mice.

2022-01-28 | GSE194389 | GEO

RNA-sequencing of gastric cancer PDX mice model after treated with CUS

Project description:RNA-sequencing of gastric cancer PDX mice model after treated with CUS

| PRJNA1090109 | ENA