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Effect of 2-deoxyglucose on the interferon gamma-mediated response to intracellular bacterial infection in mouse bone marrow-derived macrophages

ABSTRACT: Effect of 2-deoxyglucose on the interferon gamma-mediated response to intracellular bacterial infection in mouse bone marrow-derived macrophages

PROVIDER: PRJNA558699 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9906290_1.fastq.gz	Fastqsanger.gz
	SRR9906290_2.fastq.gz	Fastqsanger.gz
	SRR9906285_1.fastq.gz	Fastqsanger.gz
	SRR9906285_2.fastq.gz	Fastqsanger.gz
	SRR9906286_1.fastq.gz	Fastqsanger.gz

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Effect of 2-deoxyglucose on the interferon gamma-mediated response to intracellular bacterial infection in mouse bone marrow-derived macrophages

Project description:We report transcriptional responses of mouse macrophages to Pam3CSK4 stimulation or L. pneumophila infection that are additionally stimulated with interferon gamma ± 2-deoxyglucose. We identify a strong transcriptional signature of the unfolded protein stress response in macrophages exposed to 2-deoxyglucose. Additionally we find that 2-deoxyglucose reduces the expression of several key interferon gamma-induced transcripts associated with an antimicrobial response to L. pneumophila.

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Effect of 2-deoxyglucose and other unfolded protein response (UPR) stimuli on the interferon gamma-mediated response in mouse bone marrow-derived macrophages

Project description:Effect of 2-deoxyglucose and other unfolded protein response (UPR) stimuli on the interferon gamma-mediated response in mouse bone marrow-derived macrophages

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