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Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: telomerase-deficient vs PGC1aOE)

ABSTRACT: Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: telomerase-deficient vs PGC1aOE)

PROVIDER: PRJNA558760 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9906740.fastq.gz	Fastqsanger.gz
	SRR9906741.fastq.gz	Fastqsanger.gz
	SRR9906742.fastq.gz	Fastqsanger.gz
	SRR9906736.fastq.gz	Fastqsanger.gz
	SRR9906737.fastq.gz	Fastqsanger.gz

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Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity

Project description:Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity

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Fine-Tuning of PGC1α Expression Regulates Cardiac Function and Longevity (RNA-seq: telomerase-deficient vs PGC1aOE)

Project description:PGC1alpha plays an important role in energy metabolism and mitochondrial function in the heart, multiple attempts have failed to upregulate PGC1alpha expression as a therapy, with the underlying mechanism to be answered. We used RNA sequencing to detail the global programme of gene expression in the hearts of third generation of telomerase-deficient mice with or without cardiomyocyte-restricted PGC1alpha overexpression.

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Microarray analysis of skeletal muscle in PGC1α transgenic mice

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