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Gene and miRNA expression profiling in pediatric and adolescent and young adult rhabdomyosarcomas

ABSTRACT: Gene and miRNA expression profiling in pediatric and adolescent and young adult rhabdomyosarcomas

PROVIDER: PRJNA559159 | ENA |

REPOSITORIES: ENA

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miRNA expression profile in pediatric and adolescent and young adult rhabdomyosarcomas

Project description:miRNA expression profile in pediatric and adolescent and young adult rhabdomyosarcomas

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Gene expression profiling in pediatric and adolescent and young adult rhabdomyosarcomas

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miRNA expression profile in pediatric and adolescent and young adult rhabdomyosarcomas

Project description:Adolescents and young adults (AYA) with rhabdomyosarcoma (RMS) form a subgroup of patients whose optimal clinical management and best possible access to care remain a challenge and survival lacks behind that of children while diagnosed with histologically similar tumors. Understanding the tumor biology that differentiate children from AYA-RMS could provide critical information and drive new initiatives to improve their final outcome. MiRNA profile was evaluated in a RMS series of 49 tumor and 13 non-neoplastic tissues. MiRNAs analysis identified miR-223 over-expression and mir-431 down-regulation in AYA, validated by Real-Time PCR and miRNA ISH.

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2019-11-05 | GSE135517 | GEO

Gene and miRNA expression profiling in pediatric and adolescent and young adult rhabdomyosarcomas

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