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Transcriptome data of B cells in patients with primary Sjögren's syndrome

ABSTRACT: Transcriptome data of B cells in patients with primary Sjögren's syndrome

PROVIDER: PRJNA560177 | ENA |

REPOSITORIES: ENA

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Transcriptome data of B cells in patients with primary Sjögren's syndrome

Project description:We compared subsets of B cells as follows: Bm1 cells; CD38-IgD+, naïve B cells; CD38+IgD+, pre-germinal centre B cells; CD38highIgD+ and memory B cells; CD38±IgD that were collected from patients with primary Sjögren's syndrome. As a result, list of 623 differentially expressed genes was created. We found interferon signature genes and HLA genes were mostly up-regulated in patients compared to healthy controls.

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Project description:Sjögren's syndrome is an autoimmune disease manifesting primarily as dryness of eyes and mouth. In this study, we compared gene expression in PBMCs between age- and gender-matched patients with Sjögren's syndrome (diagnosed by ACR criteria) and healthy controls. Cells were collected in heparinized tubes and PBMCs were prepared using Ficoll.

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