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RNAseq of souble factors in RPE cells from Cryba1 conditional knockout (cKO) mice

ABSTRACT: RNAseq of souble factors in RPE cells from Cryba1 conditional knockout (cKO) mice

PROVIDER: PRJNA561830 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10018402.fastq.gz	Fastqsanger.gz
	SRR10018403.fastq.gz	Fastqsanger.gz
	SRR10018404.fastq.gz	Fastqsanger.gz
	SRR10018405.fastq.gz	Fastqsanger.gz
	SRR10018406.fastq.gz	Fastqsanger.gz

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RNAseq of souble factors in RPE cells from Cryba1 conditional knockout (cKO) mice

Project description:The study was aimed at understanding the expression of known neutrophil regulating factors in the retinal pigment epithelium (RPE) cells with increasing age in a mouse model (Cryba1 cKO, mice lacking gene which codes for beta A3/A1-crystallin protein only in the RPE cells) of age-related macular degeneration

2019-08-26 | GSE136280 | GEO

RNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas

Project description:We have shown that Chrnb4-cre; Dicerflox/flox retinas (Dicer CKO) display a cone dystrophy by postnatal day P21, independent of rod degeneration. To elucidate which gene pathways were affected by Dicer loss, RNA sequencing was performed in whole neural retinas of P21 control and Dicer CKO mice. This experiment aims to identify which genes were differentially expressed between Dicer conditional knockout and control mice.

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miRNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas

Project description:We have shown that Chrnb4-cre; Dicerflox/flox retinas (Dicer CKO) display a cone dystrophy by postnatal day P21, independent of rod degeneration. To elucidate which miRNAs were involved in such phenotype, miRNA sequencing was performed in whole retinas of P21 and 3.5 month old control and Dicer CKO mice. This experiment aims to identify which miRNAs were differentially expressed in Dicer conditional knockout mice when compared to control mice.

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2018-07-17 | GSE114945 | GEO

RNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas

Project description:RNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas

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mouse retinal pigmented epithelium (RPE)-LC/MS/MS

Project description:In this experiment, we compared the phosphorylated protein profile of Cryba1 cKO (RPE-specific) RPE tissue and that of the age-matched control samples.

2021-09-07 | PXD026777 | Pride

Brain BRCA1 conditional knockout

Project description:BRCA1 nestin CRE conditional knockout cortrices of P7 animals were compared to wildtype littermates to characterize the mutant phenotype. Keywords: expression BRCA1 conditional knockouts using nestin CRE and a null allele with an inverted neo cassette at the 5' end of the exon 11 of BRCA1 on one floxed allele flanking exons 5-13. Cortices of 3 wildtype animals were compred to 3 BRCA cKO at postnatal day 7.

2011-09-07 | E-GEOD-6310 | biostudies-arrayexpress

miRNAseq analysis of Chrnb4-cre driven Dicer conditional knockout (Dicer CKO) whole retinas

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Expression of angiogenic and inflammatory factors in CNV-derived RPE

Project description:Purpose: Anti-angiogenic treatment is well established in the management of exudative AMD, but not sufficient in all patients. Characterization of factors driving this chronic disease could serve to identify additional treatment options. The purpose of this study was to assess gene expression patterns and distinct changes in cells derived from surgically extracted CNV (chorioidal neovascularization) membranes. Materials and Methods: Expression of >11.000 genes was analyzed by means of a microarray in cells cultured from two late-stage CNV membranes, compared to primary human RPE and ARPE-19 cells. A pathway analysis was performed to identify gene expression patterns associated with exudative AMD. Results: The analysis revealed significant alterations in gene sets associated with inflammatory processes in CNV-derived cells, involving up-regulation of pro-inflammatory factors IL6, C3, and C5 and downregulation of anti-inflammatory CFB and CFI. Factors associated with angiogenesis, such as VEGFA or ANGPT2, were not significantly regulated in the two RPE-derived cell lines. Conclusion: In late-stage CNV membrane-derived RPE, gene expression was shifted towards a pro-inflammatory state. Angiogenesis-associated factors were regulated differently in the two CNV-derived RPE membranes. While inflammation seems to be continuously stimulated by RPE associated with late exudative AMD, this seems not the case with regard to angioregulatory mechanisms.

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