Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication

ABSTRACT: G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication

PROVIDER: PRJNA561862 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10018600_1.fastq.gz	Fastqsanger.gz
	SRR10018600_2.fastq.gz	Fastqsanger.gz
	SRR10018900.fastq.gz	Fastqsanger.gz
	SRR10018601_1.fastq.gz	Fastqsanger.gz
	SRR10018601_2.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 480

Similar Datasets

G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [BrdU-Seq]

Project description:G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [BrdU-Seq]

| PRJNA561836 | ENA

G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [ChIP-seq]

Project description:G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [ChIP-seq]

| PRJNA561860 | ENA

G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [Chr-RNA-seq]

Project description:G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [Chr-RNA-seq]

| PRJNA561861 | ENA

G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [Chip-Seq H2AX]

Project description:G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [Chip-Seq H2AX]

| PRJNA674611 | ENA

G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [REPLI-Seq async]

Project description:G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [REPLI-Seq async]

| PRJNA674612 | ENA

G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [G2M BrdU-Seq]

Project description:G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [G2M BrdU-Seq]

| PRJNA561863 | ENA

G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [G2M async Brdu Seq]

Project description:G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [G2M async Brdu Seq]

| PRJNA674625 | ENA

G2/M DNA synthesis at transcription start sites because of RNA transcription persistence during DNA replication [ChIP-seq]

Project description:RNA transcription and DNA replication both use DNA as a substrate, that however can be engaged only by one of them at any given time. Consequently, conflicts between transcription and replication significantly affect genome stability and human health. To understand the reciprocal interplay between transcription and replication in human cells, we performed a genome-wide analysis of the two processes throughout S-phase. We found that transcription persists during replication, with direct consequences for replication progression through genes and sites of DNA damage. Importantly however, we also found that transcription start sites will not be replicated together with the surrounding regions, and remain under-replicated throughout S-phase. DNA synthesis across transcription start sites occurs specifically when cells enter mitosis, because the RNA Polymerase II is removed at that point from the majority of the genes. Intriguingly, this G2/M DNA synthesis is not associated with increased DNA damage and occurs at very high frequency.

2021-02-17 | GSE136291 | GEO