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Profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

ABSTRACT: Profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

PROVIDER: PRJNA564273 | ENA |

REPOSITORIES: ENA

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miRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants.

Project description:miRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants.

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lncRNA and mRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

Project description:lncRNA and mRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

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miRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants.

Project description:To further understanding of miRNA expression during radioprotectation, we used microarray analysis to determine the differential expression of miRNAs in the bone marrow of mice exposed to high-dose IR with and without pretreatment with three types of radioprotectants: Amifostine (WR2721), CBLB502, and Nilestriol, as well in the hypothalamus of mice exposed to IR with and without pretreatment with amifostine. Overall, amifostine treatment led to a similar expression pattern of miRNAs to that of CBLB502 but not to that of nilestriol in bone marrow. The radioprotectants exhibited mostly opposite effects against IR-induced miRNAs. These results expand the biological function of miRNAs in mediating the activity of radioprotectants, further offering insights into the molecular mechanism underlying radioprotection.

2019-09-07 | GSE137012 | GEO

lncRNA and mRNA profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

Project description:To further understanding of lncRNA and mRNA expression during radioprotectation, we used microarray analysis to determine the differential expression of lncRNAs, and mRNAs in the bone marrow of mice exposed to high-dose IR with and without pretreatment with three types of radioprotectants: Amifostine, CBLB502, and Nilestriol, as well in the hypothalamus of mice exposed to IR with and without pretreatment with amifostine. Overall, the induction of lncRNAs and mRNAs was increased by pretreatment with all three radioprotectants. Amifostine treatment led to a similar expression pattern of lncRNAs, and mRNAs to that of CBLB502 but not to that of nilestriol. The radioprotectants exhibited mostly opposite effects against IR-induced lncRNAs, and mRNAs in bone marrow, and might induce a potential common mechanism of histone gene downregulation only in the face of IR, mainly via nucleosome assembly and related signaling pathways, which may be a common response to IR-induced biological changes and could explain the radioprotection mechanism. These results expand the biological function of lncRNAs, and mRNAs in mediating the activity of radioprotectants, further offering insights into the molecular mechanism underlying radioprotection.

2019-09-07 | GSE137011 | GEO

Profiling in radiated mice bone marrow and hypothalamus pretreated with radioprotectants

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-09-07 | GSE137013 | GEO

Gene Expression of Bone Marrow Endothelial Cells under Radiated and Radioprotective Conditions

Project description:Gene Expression of Bone Marrow Endothelial Cells under Radiated and Radioprotective Conditions

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Gene Expression of Bone Marrow Endothelial Cells under Radiated and Radioprotective Conditions

Project description:Bone Marrow Transplantation (BMT) depends greatly on transendothelial migration of stem cells from bloodstream to bone marrow. Therefore Bone Marrow Endothelial Cells (BMECs) becomes an essential component for successful BMT. Since BMT requires prior radiation therapy therefore it is necessary to study the behaviour of BMEC in irradiated and radiprotective conditions. We have conducted transcriptome profiling of Bone Marrow Endothelial Cells (BMECs) to identify the signalling mechanisms required for transendothelial migration to bone marrow under irradiated and radioprotected conditions.

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Bone Marrow Transplantation in Treating Patients With Hematologic Cancer

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Next Generation Sequencing Facilitates Quantitative Analysis of Differentially Expressed Genes in Radiated and Non-Radiated femurs

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Project description:Bone marrow niche

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