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Transcriptome and Epigenome Characterization of Long Term Trained Immunity in Cotrolled Human Malaria Model [ChIP-seq]

ABSTRACT: Transcriptome and Epigenome Characterization of Long Term Trained Immunity in Cotrolled Human Malaria Model [ChIP-seq]

PROVIDER: PRJNA564320 | ENA |

REPOSITORIES: ENA

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Transcriptome and Epigenome Characterization of Long Term Trained Immunity in Cotrolled Human Malaria Model [ChIP-seq]

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Project description:Respiratory viral infections reprogram pulmonary macrophages with altered anti-infectious functions. However, the potential function of virus-trained macrophages in antitumor immunity in the lung, a preferential target of both primary and metastatic malignancies, is not well understood. Using mouse models of influenza and lung metastatic tumors, we show here that influenza trains respiratory mucosal-resident alveolar macrophages (AMs) to exert long-lasting and tissue-specific antitumor immunity. Trained AMs infiltrate tumor lesions and have enhanced phagocytic and tumor cell cytotoxic functions, which are associated with epigenetic, transcriptional and metabolic resistance to tumor-induced immune suppression. Generation of antitumor trained immunity in AMs is dependent on interferon-γ and natural killer cells. Notably, human AMs with trained immunity traits in non-small cell lung cancer tissue are associated with a favorable immune microenvironment. These data reveal a function for trained resident macrophages in pulmonary mucosal antitumor immune surveillance. Induction of trained immunity in tissue-resident macrophages might thereby be a potential antitumor strategy.

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Transcriptome and Epigenome Characterization of Long Term Trained Immunity in Cotrolled Human Malaria Model

Project description:This SuperSeries is composed of the SubSeries listed below.

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