Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Impact Of Oil Spill To Human Lung Health – Next Generation Sequencing And Mouse Model Based Analysis

ABSTRACT: Impact Of Oil Spill To Human Lung Health – Next Generation Sequencing And Mouse Model Based Analysis

PROVIDER: PRJNA564804 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10095500_1.fastq.gz	Fastqsanger.gz
	SRR10095500_2.fastq.gz	Fastqsanger.gz
	SRR10095501_1.fastq.gz	Fastqsanger.gz
	SRR10095501_2.fastq.gz	Fastqsanger.gz
	SRR10095502_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 160

Similar Datasets

Impact Of Oil Spill To Human Lung Health – Next Generation Sequencing And Mouse Model Based Analysis

Project description:This project addresses the question of impact of oil spills on lung health. Specifically the project will address the general hypothesis, which is upon oil/dispersant respiratory exposure there will be a higher carcinogenic potential of lung tissue.

2020-08-26 | GSE137204 | GEO

The impact of oil spill to lung health – insights from an RNA-seq study of human airway epithelial cells

Project description:To reveal the potential effects of oil and oil dispersants on the respiratory system at the molecular level, we evaluated the transcriptomic profile of human airway epithelial cells grown under treatment of crude oil, the dispersants Corexit 9500 and Corexit 9527 and oil-dispersant mixtures. We identified a very strong effect of Corexit 9500 treatment, with 84 genes (response genes) differentially expressed in treatment vs. control samples. We discovered an interactive effect of oil + dispersant mixtures; while no response gene was found for Corexit 9527 treatment alone, cells treated with Corexit 9527 + oil mixture showed an increased number of response genes (46 response genes), suggesting a synergic effect of 9527 with oil on the transcriptomic perturbation of airway epithelial cells. Through GO (gene ontology) functional term and pathway-based analysis, we identified upregulation of genes involved in angiogenesis and immune responses and downregulation of genes involved in cell junctions and steroid synthesis as the prevailing transcriptomic signatures in the cells treated with Corexit 9500, oil or Corexit 9500 + oil mixture. Interestingly, these key molecular features coincide with those observed in common lung diseases, such as asthma, cystic fibrosis and chronic obstructive pulmonary disease. Our study provides mechanistic insights into the detrimental effects of oil and oil dispersants to the respiratory system and suggested significant health impacts of the recent BP oil spill to those people involved in the cleaning operation.

2017-08-24 | GSE70909 | GEO

BP oil spill field study 2010

Project description:BP oil spill field study 2010

2011-10-20 | E-MTAB-663 | biostudies-arrayexpress

Oil spill impacted sediments

Project description:Oil spill impacted sediments

| PRJEB14882 | ENA

Impact of an Oil Spill in the Gulf of Mexico

Project description:Combined effects of an Oil Spill, surfactant and solar radiation on surface marine microbiome in the Gulf of Mexico

2023-12-21 | PXD048022 |

Transcriptome response to the Deepwater Horizon oil spill identifies novel candidate genes for oil tolerance in natural populations of the foundation plant Spartina alterniflora

Project description:Genome-wide expression assay of S. alterniflora individuals from populations (4 from Louisiana, 2 from Mississippi) either exposed or unexposed to the Deepwater Horizon oil spill

2018-05-19 | GSE114635 | GEO

Deepwater Horizon oil spill sediments

Project description:Deepwater Horizon oil spill sediments Metagenome

| PRJNA796582 | ENA

Microphytobenthic communities in simulated oil spill seagrass mesocosm

Project description:Microphytobenthic communities in simulated oil spill seagrass mesocosms

| PRJNA630525 | ENA

BP oil spill - field - gill

Project description:In this study we characterize the gill transcriptome changes that coincide with the arrival of contaminating oil in field-collected Gulf killifish Fundulus grandis. Gill transcription was contrasted before and after the arrival of oil, and between oil impacted and reference sites. Animals were sampled from field sites at four times. The oil impacted site is Grand Terre Island Louisiana (GT) and the two reference sites are Bay St. Louis Mississippi (BSL) and Bayou La Batre Alabama (BLB). The first timepoint (05/01/2010 to 05/09/2010) was before the arrival of contaminating oil, the second and third timepoints (06/28/2010 to 06/29/2010, and 08/30/2010 to 09/01/2010) were after the arrival of contaminating oil, and the fourth timepoint 08/28/2011) was over a year after the arrival of contaminating oil.

2013-04-18 | E-MTAB-1622 | biostudies-arrayexpress

Next generation sequencing analysis of fetal brown adipose tissue in response to maternal fish oil intake

Project description:We report the impact of maternal fish oil intake during gestation and lactation on the fetal brown fat development and metabolic health in later life

2022-03-19 | GSE198813 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data