Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ABSTRACT: Custom targeted sequencing on Leukemias from MCM2 transgenic mice

PROVIDER: PRJNA565492 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10119900_1.fastq.gz	Fastqsanger.gz
	SRR10119900_2.fastq.gz	Fastqsanger.gz
	SRR10119901_1.fastq.gz	Fastqsanger.gz
	SRR10119901_2.fastq.gz	Fastqsanger.gz
	SRR10119902_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 182

Similar Datasets

Project description:Whole exome sequencing of leukemias from MCM2 transgenic mice

| PRJNA799024 | ENA

Project description:Whole exome sequencing of leukemias from MCM2 transgenic mice

| PRJNA565494 | ENA

Project description:Whole genome sequencing of leukemias from MCM2 transgenic mice

| PRJNA565491 | ENA

Leukemias from NP23-NHD13 double transgenic mice - WES study

Project description:Whole exome sequencing (the SureSelectXT Mouse All Exon Kit) was done on leukemias from NP23-NHD13 double transgenic mice with strain background designated “C57Bl6-NIH”.

2020-09-10 | GSE137542 | GEO

Leukemias from NP23-NHD13 double transgenic mice - WES study

Project description:Leukemias from NP23-NHD13 double transgenic mice - WES study

| PRJNA565806 | ENA

Project description:Whole exome sequencing of leukemias from NP23-NHD13 double transgenic mice

| PRJNA565250 | ENA

Effect of mini-chromosome maintenance protein 2 deficiency on the locations of DNA replication origins

Project description:Mini-chromosome maintenance (MCM) proteins are loaded to chromatin during G1-phase and define potential locations of DNA replication initiation. MCM protein deficiency results in genome instability and high rates of cancer in mouse models. Here we develop a method of nascent strand capture and release and show that MCM2 deficiency reduces DNA replication initiation in gene rich regions of the genome. DNA structural properties are shown to correlate with sequence motifs associated with replication origins and with locations that are preferentially affected by MCM2 deficiency. Reduced nascent strand density correlates with sites of recurrent focal CNVs in tumors arising in MCM2-deficient mice, consistent with a direct relationship between sites of reduced DNA replication initiation and genetic damage. Between 10 and 90% of human tumors, depending on type, carry heterozygous loss or mutation of one or more Mcm2-7 genes which is expected to compromise DNA replication origin licensing and result in elevated rates of genome damage at a subset of gene rich locations. Mcm2 deficient vs. wild type

2015-01-14 | E-GEOD-64933 | biostudies-arrayexpress

Mus musculus

Project description:Targeted sequencing of Berkeley and Townes transgenic mice

| PRJNA750406 | ENA

Mcm2 promotes stem cell differentiation via its ability to bind H3-H4 (ChIP-Seq)

Project description:Mcm2, a subunit of the Mcm2-7 helicase best known for its role in DNA replication, contains a histone binding motif that facilitates the transfer of parental histone following DNA replication. Here we show that Mcm2 is important for the differentiation of mouse embryonic stem (ES) cells. Mcm2-2A mutation defective in histone binding impairs differentiation and programmatic changes in gene expression and histone modifications during differentiation. Mcm2 localizes at the transcription starting sites and the binding of Mcm2 at gene promoters is disrupted in both Mcm2-2A ES cells and neuro-precursor cells (NPCs). Reduced Mcm2 binding in Mcm2-2A ES cells correlates with decreased chromatin accessibility at bivalent chromatin domains containing repressive H3K27me3 and active H3K4me3 modifications in NPCs. Together, our studies reveal a novel function of Mcm2 in ES differentiation, likely through manipulating chromatin landscape at bivalent chromatin domains.

2022-11-16 | GSE203270 | GEO

Expression data from mouse T-cell lymphomas

Project description:Transgenic expression of TLX1 induces T-cell leukemias in mice. We used microarrays to identify the gene expression signatures associated with TLX1 tumors compared with different genetic models T acute lymphoblastic lymphoma.

2010-10-19 | GSE19499 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data