Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic Characterization of neuroblastoma by Single Cell RNA Sequencing

ABSTRACT: Transcriptomic Characterization of neuroblastoma by Single Cell RNA Sequencing

PROVIDER: PRJNA573097 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10156300.fastq.gz	Fastqsanger.gz
	SRR10156301.fastq.gz	Fastqsanger.gz
	SRR10156302.fastq.gz	Fastqsanger.gz
	SRR10156303.fastq.gz	Fastqsanger.gz
	SRR10156304.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 70

Similar Datasets

Transcriptomic Characterization of neuroblastoma by Single Cell RNA Sequencing

Project description:Neuroblastoma (NB) is the most common malignant solid tumor in the abdomen of children, with high degree of malignancy, poor prognosis and unknown pathogenesis. So we aim to investigate intra-tumor heterogeneity of neuroblastoma at single cell resolution.

2020-09-18 | GSE137804 | GEO

Single-cell transcriptomic characterization primary HNSCC tumors

Project description:Single-cell transcriptomic characterization primary HNSCC tumors

| PRJNA727663 | ENA

Single cell RNA sequencing data of neuroblastoma infiltrated bone marrow

Project description:We report transcriptional analyses at single cell resolution of 16 bone marrow samples with and without neuroblastoma infiltration. Our samples span across several neuroblastoma models, including MYCN amplified, ATRX mutated, and sporadic (lacking either alteration).

2023-04-26 | GSE216155 | GEO

Joint single-nucleus RNA sequencing and single-nucleus ATAC sequencing of neuroblastoma cell lines

Project description:This study was undertaken to assess transcriptional and epigenetic heterogeneity a the level of individual cells within neuroblastoma cell lines, and to compare cell lines with MYCN amplificaion to cell lines without MYCN amplification. Methods: We used 10X Genomics multiome sequencing technology to perform joint gene expression and ATAC profiling on thousands of nuclei isolated from the following human neuoblastoma cell lines: SHSY5Y, SK-N-AS, SK-N-SH, SK-N-DZ, Be-2c, and CHP134. Results: We found considerable gene expression and epigeneic heterogeneity both within and between neuroblastoma cell lines. Conclusion: Joint single-nucleus RNA sequencing and single-nucleus ATAC sequencing has demonsrated that neuroblastoma cell lines are heterogeneous, which may have implications for therapeutic strategies.

2024-09-17 | GSE262189 | GEO

Single-cell transcriptomics of neuroblastoma tumors

Project description:Neuroblastoma is a rare embryonic tumor arising from neural crest development and is responsible for 15% of pediatric cancer-related deaths. Over the past years, several single-cell transcriptome studies were performed to investigate the cell-of-origin and tumor heterogeneity. These individual studies typically involved a limited number of neuroblastoma tumors. To overcome this limitation, we integrated seven single-cell or single-nucleus data sets into a harmonized cell atlas covering 362,991 cells across 68 patient samples. We use this integrated atlas to decipher the transcriptional tumoral landscape of neuroblastoma at single-cell resolution. Notably, within the tumor compartment, we find associations between transcriptomic profiles and clinical outcomes. In addition, we characterize the complex immune cell landscape of neuroblastoma and uncover considerable heterogeneity amongst tumor-associated macrophages. Finally, we showcase the utility of our atlas as a resource by expanding it with new data and using it as a reference for data-driven cell type prediction.

2024-08-29 | GSE253865 | GEO

Single cell ATAC sequencing data of neuroblastoma infiltrated bone marrow

Project description:We report genome-wide ATAC-seq analyses at single cell resolution of 16 bone marrow samples with and without neuroblastoma infiltration. Our samples span across several neuroblastoma models, including MYCN amplified, ATRX mutated, and sporadic (lacking either alteration).

2023-04-26 | GSE216175 | GEO

Joint single-nucleus RNA sequencing and single-nucleus ATAC sequencing of neuroblastoma cell lines

Project description:Joint single-nucleus RNA sequencing and single-nucleus ATAC sequencing of neuroblastoma cell lines

| PRJNA1090535 | ENA

Transcriptomic Characterization of Local Invasion in Human Bladder Cancer by Single Cell RNA Sequencing

Project description:Transcriptomic Characterization of Local Invasion in Human Bladder Cancer by Single Cell RNA Sequencing

| PRJNA558456 | ENA

Single cell RNA sequencing data of neuroblastoma infiltrated bone marrow

Project description:Single cell RNA sequencing data of neuroblastoma infiltrated bone marrow

| PRJNA892452 | ENA

Single cell RNA-Seq of Neuroblastoma cell line (CLB-berlud)

Project description:We report the application of single-molecule-based sequencing technology for high-throughput profiling of Neuroblastoma cell line (CLB-berlud) Examination of gene expression in Neuroblastoma cell line (CLB-berlud), as a negative control

2020-02-14 | GSE130022 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data