Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Rhinovirus-induced human lung tissue responses mimic respiratory disease signatures allowing evaluation of therapeutics

ABSTRACT: Rhinovirus-induced human lung tissue responses mimic respiratory disease signatures allowing evaluation of therapeutics

PROVIDER: PRJNA573839 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Rhinovirus-induced human lung tissue responses mimic respiratory disease signatures allowing evaluation of therapeutics

Project description:Human rhinovirus (RV) is a major risk factor for COPD and asthma exacerbations, but exploration of RV pathogenesis has been hampered by a lack of disease relevant model systems. We performed a detailed characterization of host mRNA responses to RV infection in human precision cut lung tissue ex vivo (comparing to previously published asthma and COPD studies) and explored the impact of antiviral treatment. Genomic analyses revealed that RV not only induced anti-viral immune responses but also triggered changes in epithelial cell-associated pathways. Strikingly, the RV response in PCLS was reflective of gene expression changes described previously in COPD and asthma patients. While RV-induced host immune responses were abrogated by rupintrivir, RV-triggered epithelial processes were largely refractory to antiviral treatment.

2021-09-01 | GSE137905 | GEO

Genome-wide analysis of whole blood transcriptional response to Respiratory Syncytial Virus, Influenza and Rhinovirus lower respiratory tract infection (LRTI) in children

Project description:Analysis of transcriptional profiles in whole blood from children < 2 years of age (and healthy matched controls) with RSV, rhinovirus and influenza infection. The hypothesis tested is that transcriptional profile heterogeneity will reflect patient clinical heterogeneity and that RSV infection induces a distinct host response compared with influenza and rhinovirus infection Total RNA extracted from whole blood (lysed in Tempus tubes) drawn from individual pediatric patients with acute RSV, influenza and Rhinovirus lower respiratory tract infection. A total of 241 samples are analyzed: 135 with acute RSV LRTI, 30 with Rhinovirus LRTI, 16 with influenza LRTI, 39 age-sex matched healthy controls and 21 samples obtained one month after the acute hospitalization in children with RSV. Samples GSM1226237-GSM1226272, which were hybridized to Platform GPL10558, were normalized separately from the other Samples in this Series, which were hybridized to Platform GPL6884. 'GSE38900_non-normalized_GSM1226237-GSM1226272.txt.gz' includes the non-normalized data for Samples GSM1226237-GSM1226272; 'GSE38900_non-normalized.txt.gz' includes the non-normalized data for the other Samples.

2013-11-12 | E-GEOD-38900 | biostudies-arrayexpress

Genome-wide analysis of whole blood transcriptional response to Respiratory Syncytial Virus, Influenza and Rhinovirus lower respiratory tract infection (LRTI) in children

2013-11-12 | GSE38900 | GEO

Rhinovirus C

Project description:Human rhinovirus C

| PRJNA41899 | ENA

Rhinovirus C

Project description:Human rhinovirus C overview

| PRJNA69715 | ENA

Human rhinovirus sp.

Project description:Human rhinovirus sp.

| PRJNA32533 | ENA

Rhinovirus B

Project description:Rhinovirus B Raw sequence reads

| PRJNA984283 | ENA

Human rhinovirus sp.

Project description:Human rhinovirus sp. overview

| PRJNA70485 | ENA

Global transcriptional changes induced by rhinovirus infection in-vitro

Project description:Cell lines B2B and 16HBE were infected in-vitro with rhinovirus 16 and comparisons were made to mock-infected cultures and cultures exposed to UV-irradiated rhinovirus. Total RNA were extracted and assessed by whole genome expression arrays. Rhinovirus in-vitro infected cell lines harvested at different time points (T hours) in biological triplicates. Total RNA extracted directly upon harvest.

2014-04-01 | E-GEOD-28904 | biostudies-arrayexpress

Human rhinovirus sp.

Project description:Human Rhinovirus genome sequencing project

| PRJNA60025 | ENA