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Transcriptional profile of Tim-3+ and Tim-3- CD8+ T cells from trigeminal ganglion 8 days post HSV-1 infection

ABSTRACT: Transcriptional profile of Tim-3+ and Tim-3- CD8+ T cells from trigeminal ganglion 8 days post HSV-1 infection

PROVIDER: PRJNA574060 | ENA |

REPOSITORIES: ENA

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Transcriptional profile of Tim-3+ and Tim-3- CD8+ T cells from trigeminal ganglion 8 days post HSV-1 infection

Project description:The goal of this study was to compare the transcriptional profile between different subpopulations of CD8+ T cells in the trigeminal ganglion 8 days post HSV-1 infection. Within the HSV-1 infected TG, essentially all of the CD8+ T cells are virus specific and by using a tetramer for the immunodominant epitope from glycoprotein B (gB), we can separate the CD8+ T cell response into two populations: the gB-CD8+ T cells and the Subdom-CD8+ T cells. These populations have different levels of functionality during viral latency and express different checkpoint molecules that may influence this. Past work has shown that expression of PD-1 is associated with impaired functionality in this model and we are currently investigating the role of Tim-3, as there is little overlap in expression between Tim-3 and PD-1 and Tim-3 appears to mark functional cells when assessed by flow cytometry. By sorting cells first by using tetramer to create two populations of CD8+ T cells and then further separating these populations using expression of Tim-3 and PD-1, we have isolated subpopulations to assess what genes are up and downregulated in Tim-3+ cells compared to Tim-3- cells in each population.

2019-09-26 | GSE137973 | GEO

The transcriptional landscape of the developing chick trigeminal ganglion

Project description:The trigeminal ganglion is a critical structure in the peripheral nervous system, responsible for transmitting sensations of touch, pain, and temperature from craniofacial regions to the brain. Trigeminal ganglion development depends upon intrinsic cellular programming as well as extrinsic signals exchanged by diverse cell populations. With its complex anatomy and dual cellular origin from cranial placodes and neural crest cells, the trigeminal ganglion offers a rich context for examining diverse biological processes, including cell migration, fate determination, adhesion, and axon guidance. Avian models have, so far, enabled key insights into craniofacial and peripheral nervous system development. Yet, the molecular mechanisms driving trigeminal ganglion formation and subsequent nerve growth remain elusive. In this study, we performed RNA-sequencing at multiple stages of chick trigeminal ganglion development and generated a novel transcriptomic dataset that has been curated to illustrate temporally dynamic gene expression patterns. This publicly available resource identifies major pathways involved in trigeminal gangliogenesis, particularly with respect to the condensation and maturation of placode-derived neurons, thus inviting new lines of research into the essential processes governing trigeminal ganglion development.

2025-01-01 | GSE282770 | GEO

Effects of Nogo-A deletion on the trigeminal ganglion

Project description:Nogo-A is a major regulator of neural development and regeneration in the central nervous system, but its role in tooth innervation remains largely unknown. Neurons of the trigeminal ganglion innervate the teeth. We showed that Nogo-A is expressed in the trigeminal ganglion and tooth-related nerve fibres. Nogo-A deletion in mice leads to a less complex neuronal network when compared to wild-type animals. Bulk RNA sequencing on the trigeminal ganglia of Nogo-A KO and wild-type mice revealed gene expression changes associated with alterations in neurotrophin signalling and neuronal synaptic formation during the development and maturation of the trigeminal neurons.

2024-12-04 | GSE283391 | GEO

Gene expression profile at single cell level of trigeminal ganglion non-neuronal cells

Project description:Trigeminal ganglion non-neuronal cells contain glial, endothelila, smooth muscle, immune cells and fibroblasts.

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Proteomics of exosomes derived from rat trigeminal ganglion neurons

Project description:Exosomes derived from rat trigeminal ganglion neurons (TGN) were harvested as control group. Exosomes derived from TGN after internalizing exosomes derived from stem cells from human exfoliated deciduous teeth (S-Exo) were harvested as treatment group.

2024-01-22 | PXD048746 |

Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine

Project description:The sensitization of trigeminal ganglion neurons contributes to primary headache disorders such as migraine, but the specific neuronal and non-neuronal trigeminal subtypes involved remain unclear. We thus developed a cell atlas in which human and mouse trigeminal ganglia are transcriptionally and epigenomically profiled at single-cell resolution. These data describe evolutionarily conserved and human-specific gene expression patterns within each trigeminal ganglion cell type, as well as the transcription factors and gene regulatory elements that contribute to cell-type-specific gene expression. We then leverage these data to identify trigeminal ganglion cell types that are implicated both by human genetic variation associated with migraine and two mouse models of headache. This trigeminal ganglion cell atlas improves our understanding of the cell types, genes, and epigenomic features involved in headache pathophysiology and establishes a rich resource of cell-type-specific molecular features to guide the development of more selective treatments for headache and facial pain.

2022-02-26 | GSE197289 | GEO

The transcriptional landscape of the developing chick trigeminal ganglion

Project description:The transcriptional landscape of the developing chick trigeminal ganglion

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Effects of Nogo-A deletion on the trigeminal ganglion

Project description:Effects of Nogo-A deletion on the trigeminal ganglion

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RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

Project description:RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

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RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

Project description:The epigenetic roles in trigeminal neuralgia (TN) still remain unclear. H3K9ac alteration in neuralgia is obscure and controversy. In this study, we established TN rat model via chronic compression, and further treated with 100 mg/kg/d carbamazepine (CBZ). RNA-seq were conducted to investigate the transcriptional profilings in control, TN and TN+CBZ.

2021-08-02 | E-MTAB-10792 | biostudies-arrayexpress

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