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Transcriptional profile of Tim-3+ and Tim-3- CD8+ T cells from trigeminal ganglion 8 days post HSV-1 infection

ABSTRACT: Transcriptional profile of Tim-3+ and Tim-3- CD8+ T cells from trigeminal ganglion 8 days post HSV-1 infection

PROVIDER: PRJNA574060 | ENA |

REPOSITORIES: ENA

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Transcriptional profile of Tim-3+ and Tim-3- CD8+ T cells from trigeminal ganglion 8 days post HSV-1 infection

Project description:The goal of this study was to compare the transcriptional profile between different subpopulations of CD8+ T cells in the trigeminal ganglion 8 days post HSV-1 infection. Within the HSV-1 infected TG, essentially all of the CD8+ T cells are virus specific and by using a tetramer for the immunodominant epitope from glycoprotein B (gB), we can separate the CD8+ T cell response into two populations: the gB-CD8+ T cells and the Subdom-CD8+ T cells. These populations have different levels of functionality during viral latency and express different checkpoint molecules that may influence this. Past work has shown that expression of PD-1 is associated with impaired functionality in this model and we are currently investigating the role of Tim-3, as there is little overlap in expression between Tim-3 and PD-1 and Tim-3 appears to mark functional cells when assessed by flow cytometry. By sorting cells first by using tetramer to create two populations of CD8+ T cells and then further separating these populations using expression of Tim-3 and PD-1, we have isolated subpopulations to assess what genes are up and downregulated in Tim-3+ cells compared to Tim-3- cells in each population.

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RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

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RNA-seq: H3K9ac regulated by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

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ChIP-seq to investigate H3K9ac regulation by HDAC3 in trigeminal ganglion of SD rat trigeminal neuralgia model

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Project description:Orofacial inflammation could lead to transcriptional alterations in the trigeminal ganglion (TG). In this study, we performed single-cell RNA-sequencing (scRNA-seq) analysis of mouse TG to identify all cell types and profile transcriptomic alterations of TG cells under inflammatory conditions. A total of 7 types of cells including endothelial cells, fibroblasts, glial cells, granulocytes, lymphocytes, monocyte-macrophages and several subtypes of neurons were identified. In addition, we performed annotation of neuronal subtypes and differential gene expression analysis among TG neurons, identifying several differential genes involved in pain modulation such as Scn10a, Zbtb20 and Runx1. Collectively, our study revealed the heterogeneity of TG cells and diverse neuronal transcriptomic responses to orofacial inflammation, which aids in the development of novel therapeutics for orofacial inflammatory pain.

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