Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

MRNA sequencing of highly and lowly metastatic human colorectal cancer PDXs

ABSTRACT: mRNA sequencing of highly and lowly metastatic human colorectal cancer PDXs

PROVIDER: PRJNA575218 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10210475.fastq.gz	Fastqsanger.gz
	SRR10210476.fastq.gz	Fastqsanger.gz
	SRR10210477.fastq.gz	Fastqsanger.gz
	SRR10210478.fastq.gz	Fastqsanger.gz
	SRR10210479.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

mRNA sequencing of highly and lowly metastatic human colorectal cancer PDXs

Project description:We performed in-vivo selection of human patient derived colorectal cancer xenografts. 4 independent highly-liver metastatic sub-lines (lvm PDXs) were generated. Those lvm PDXs were harvested with the corresponding parental PDX tumors from mice and then we performed MACS mice cell depletion followed by FACS sorting to obtain human EpCAM positive and mice MHC negatitve populations. total RNA was extracted from those ex-vivo tumors and high-throuput sequencing was performed

2019-10-02 | GSE138248 | GEO

Transcriptomic profiling of highly- and lowly- metastasizing pancreatic ductal carcinoma cells [mRNAseq shNPTX1]

Project description:To interrogate transcriptomic changes in highly liver metastatic pancreatic ductal carcinoma cells as relative to their isogenic lowly metastatic cells

2024-04-20 | GSE201176 | GEO

Transcriptomic profiling of highly- and lowly- metastasizing pancreatic ductal carcinoma cells [mRNAseq in vivo selection]

Project description:To interrogate transcriptomic changes in highly liver metastatic pancreatic ductal carcinoma cells as relative to their isogenic lowly metastatic cells

2024-04-20 | GSE201175 | GEO

RNA-seq of Highly Metastatic and Lowly Metastatic 4T1 Single Clones Treated with Iron Chelator Deferasirox (DFX)

Project description:RNA-seq of Highly Metastatic and Lowly Metastatic 4T1 Single Clones Treated with Iron Chelator Deferasirox (DFX)

| PRJNA902387 | ENA

RNA-seq of Highly Metastatic and Lowly Metastatic 4T1 Single Clones Treated with Iron Chelator Deferasirox (DFX)

Project description:Using bulk RNA-seq, the transcriptional profile of two cell lines with high or low metastatic properties derived from single clones of the murine 4T1 cell line treated or untreated with iron chelator DFX was analyzed in order to determine the mechanism underlying the inhibition preference of DFX for highly metastatic 4T1 cells.

2022-11-16 | GSE218133 | GEO

RNAseq analysis on metastatic Colorectal Cancer

Project description:In this study we want present a bank of metastatic colorectal cancer (mCRC) Patient Derived Organoids (PDOs) obtained from Patient Derived Xenografts (PDXs). These models are annotated with different omics to advance our understanding of CRC. We wanted to create a resource for the scientific community to assess the predictive reliability of these preclinical models. We performed comparative analyses between PDOs and matched PDXs to assess the similarities of these two platforms regarding molecular profiles and transcriptional classification. Moreover, we analyzed how these models respond to Cetuximab, a chimeric monoclonal antibody, normally given to patients after chemotherapy, that inhibits EGFR. After having assessed models’ reliability with Cetuximab, we aimed at identifying potential synergistic drugs to individuate new possible therapeutic prospects.

2023-03-01 | GSE204805 | GEO

Transcriptomic profiling of highly- and lowly- metastasizing pancreatic ductal carcinoma cells

Project description:Transcriptomic profiling of highly- and lowly- metastasizing pancreatic ductal carcinoma cells

| PRJNA828598 | ENA

Gene expression signature for highly liver metastatic colon cancer cell line

Project description:The goal was to identify genes that promote liver metastasis of colorectal cancer. Microarray analysis was performed to compare gene expression and altered biological pathways between a poorly metastatic CT26 cell line as compared to an isogenic highly metastatic CT26 FL3 cell line that was isolated by in vivo selection in an orthotopic mouse model of colon cancer metastasis to the liver. Gene expression in CT26-FL3 and parental CT26 cells were determined using the Agilent platform. Four independent samples each were analyzed.

2016-03-30 | E-GEOD-67675 | biostudies-arrayexpress

Transcriptomic profiling of highly- and lowly- metastasizing pancreatic ductal carcinoma cells [mRNAseq shNPTX1]

Project description:Transcriptomic profiling of highly- and lowly- metastasizing pancreatic ductal carcinoma cells [mRNAseq shNPTX1]

| PRJNA828602 | ENA

Gene expression signature for highly liver metastatic colon cancer cell line

2016-03-30 | GSE67675 | GEO