Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Differential transcriptional responses in human cardiomyocytes

ABSTRACT: Differential transcriptional responses in human cardiomyocytes

PROVIDER: PRJNA575223 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10210700.fastq.gz	Fastqsanger.gz
	SRR10210701.fastq.gz	Fastqsanger.gz
	SRR10210702.fastq.gz	Fastqsanger.gz
	SRR10210703.fastq.gz	Fastqsanger.gz
	SRR10210704.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 50

Similar Datasets

Differential transcriptional responses in human cardiomyocytes

Project description:We report the application of a pericentriolar material 1 (PCM-1) based cardiomyocyte-specific nuclear isolation protocol on human cardiac tissue to specifically ask what transcriptional changes occur in cardiomyocytes of humans with atrial fibrillation. We performed RNA-sequencing on the cardiomyocyte-specific nuclear RNA and found that there are more differentially dysregulated (1343) than similarly regulated transcripts (99) in the right versus left atria. This study is the first of its kind aimed at understanding the transcriptional changes that occur specifically in the left and right atrial cardiomyocytes of humans with atrial fibrillation.

2020-09-11 | GSE138252 | GEO

CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes

Project description:CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes

| PRJNA564110 | ENA

FOXP2 regulates differential transcriptional programs in human subplate

Project description:FOXP2 regulates differential transcriptional programs in human subplate

| PRJNA436813 | ENA

Differential gene expression in human RAF1 S257L/+ and isogenic corrected iPSC-derived cardiomyocytes

Project description:Differential gene expression in human RAF1 S257L/+ and isogenic corrected iPSC-derived cardiomyocytes

| PRJNA542591 | ENA

Differential transcriptional responses to BIRC6 depletion between BIRC6-dependent and -nondependent cells

Project description:Differential transcriptional responses to BIRC6 depletion between BIRC6-dependent and -nondependent cells

| PRJNA914287 | ENA

Differential gene expression in human RAF1 S257L/+ and isogenic corrected iPSC-derived cardiomyocytes

Project description:Although several studies have uncovered abnormal signaling pathways in RASopathy disorders, little is known about the alterations of the cardiac transcriptome induced by Noonan syndrome (NS) mutations. Hence, to gain insights into the transcriptional alterations induced by the NS-associated RAF1S257L/+ mutation in human iPSC-derived cardiomyocytes, we performed quantitative transcriptome profiling by RNA-sequencing. Since we have found that inhibition of ERK5 and MEK1/2 pathways could normalized hypertrophy and myofibrillar disarray in mutant cardiomyocytes, we also aimed at identifying gene transcriptional profiles that were specifically affected by either MEK5-ERK5 or MEK1/2-ERK1/2 activation in RAF1S257L/+ iCMs.

2019-06-15 | GSE131069 | GEO

Transcriptional responses to IFN-alpha in human dermal fibroblasts

Project description:Transcriptional responses to IFN-alpha in human dermal fibroblasts

| PRJNA490086 | ENA

Transcriptional responses of human melanoma cells to EZH2 inhibition

Project description:Transcriptional responses of human melanoma cells to EZH2 inhibition

| PRJNA589591 | ENA

ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes

Project description:ETV1 activates a rapid conduction transcriptional program in rodent and human cardiomyocytes

| PRJNA473586 | ENA

CYP2J2 Modulates Diverse Transcriptional Programs in Adult Human Cardiomyocytes

Project description:CYP2J2, a member of the Cytochrome P450 family of enzymes, is the most abundant epoxygenase in the heart and has multifunctional properties including bioactivation of epoxyeicosatrienoic acids, which, in turn, have been implicated in mediating several cardiovascular conditions. In order to elucidate the complex role played by CYP2J2 in cardiac tissue, we performed targeted silencing of CYP2J2 expression in human adult cardiomyoctes and interrogated whole genome transcriptional responses. We found that knockdown of CYP2J2 elicits widespread alterations in gene expression of ventricular cardiomyocytes and leads to the activation of a diverse repertoire of programs, including those involved in ion channel signaling, development, extracellular matrix, and metabolism. Several members of the differentially up-regulated ion channel module have well-known pathogenetic roles in cardiac dysrhythmias. By leveraging causal network and upstream regulator analysis, we identified several candidate drivers of the observed transcriptional response to CYP2J2 silencing; these master regulators have been implicated in aberrant cardiac remodeling, heart failure, and myocyte injury and repair. Collectively, our study demonstrates that CYP2J2 plays a central and multifaceted role in cardiomyocyte homeostasis, and provides a framework for identifying critical regulators and pathways influenced by this gene.

2020-03-07 | GSE136957 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data