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A T cell immune suppression signature distinguishes European American auto-antibody positive (ANA+) healthy individuals

ABSTRACT: A T cell immune suppression signature distinguishes European American auto-antibody positive (ANA+) healthy individuals

PROVIDER: PRJNA575735 | ENA |

REPOSITORIES: ENA

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A T cell immune suppression signature distinguishes European American auto-antibody positive (ANA+) healthy individuals

Project description:Anti-nuclear antibody (ANA) positivity is a principal feature of individuals with an autoimmune disease, yet up to one in five healthy individuals are ANA+ and most will never develop clinical autoimmunity. Here, we show that immune profiles in ANA+ healthy individuals are altered, and differ by race. A suppressive immune signature distinguished by reduced T cell numbers and altered gene expression of HLA class I, IFN-associated, and apoptosis pathways, characterized European American (EA) ANA+ healthy individuals. In contrast, African American (AA) ANA+ healthy individuals had more elements of activation with increased CD69 gene expression on T cells and heightened pro-inflammatory cytokines. Increases in STAT4, IFNGR2 and STAT1 T cell transcripts and decreases in TGFBR1 gene expression in monocytes correlated with T cell expansion and clinical SLE. Thus, a suppressive immune signature in EA ANA+ healthy individuals may avert clinical autoimmune disease, which is associated with activation of Type I and II IFN pathways and T cell expansion.

2020-11-27 | GSE138400 | GEO

Gene Expression profiling of human PBMCs with different ANA titer

Project description:Total 48 samples with different ANA titer were analyzed for their gene expression profiles with Illumina HumanWG-6 V3 chips 10 healthy control (HC) samples with high ANA, 7 first degree relative of SLE patientw (FDR) with high ANA, 10 HCs with low ANA, 6 FDR with low ANA, 15 SLE patients (SLE) with high ANA were used for the microarray analysis.

2010-10-15 | E-GEOD-24706 | biostudies-arrayexpress

Shewanella sp. ANA-3

Project description:Shewanella sp. ANA-3

| PRJNA254924 | ENA

Transcript structures in Shewanella sp ANA-3

Project description:5' RNASeq of mRNA from Shewanella sp ANA-3 grown aerobically in Luria-Bertani broth (LB) and defined lactate minimal medium

2013-03-21 | GSE45311 | GEO

Expression data from different levels of ANA in HIV+ people

Project description:Different focal adhesions, gap junction, adherens junction, and tight junction, TLR signaling pathway were seen when compared the HIV+ high ANA (anti-nuclear antibodies) group with low ANA group We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

2018-10-01 | GSE101589 | GEO

ANA-1 macrophages infected with Chlamydia pneumoniae

Project description:This experiment is an additional experiment to GSE6688. Mouse macrophages (ANA-1 cells) were infected in vitro with C. pneumoniae with a M.O.I. of 10. Twenty two genes were significantly upregulated. Examples of the most upregulated genes in mouse macrophages after C. pneumoniae infection are serum amyloid A3 (saa3), a protein that is mainly produced by activated macrophages during tissue injury or inflammation, MIP-2 (cxcl2) and irg1. Expression levels of all genes induced by C. pneumoniae in macrophages in vitro correlated with the results obtained from infected lungs from wild type mice (GSE6688), suggesting that this cell type participates in host defense in vivo against C. pneumoniae. Keywords: Chlamydia pneumoniae, ANA-1 macrophages, in vitro, infection

2007-03-27 | GSE6690 | GEO

Gene Expression profiling of human PBMCs with different ANA titer

Project description:Total 48 samples with different ANA titer were analyzed for their gene expression profiles with Illumina HumanWG-6 V3 chips

2010-10-15 | GSE24706 | GEO

Shewanella sp. ANA-3

Project description:Shewanella sp. ANA-3 DAP-Seq epigenomics

| PRJNA757861 | ENA

Shewanella sp. ANA-3

Project description:Transcript structures in Shewanella sp ANA-3

| PRJNA193546 | ENA

Shewanella sp. ANA-3

Project description:Shewanella sp. ANA-3 transposon fitness other