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RNAseq in Arabidopsis prefoldin mutants

ABSTRACT: RNAseq in Arabidopsis prefoldin mutants

PROVIDER: PRJNA575853 | ENA |

REPOSITORIES: ENA

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RNAseq in Arabidopsis prefoldin mutants

Project description:This GEO submission includes RNAseq raw data (fastq.gz) and processed data (using DESeq2) from samples obtained in the wild type and the pfd4 and 6x_pfd mutants

2020-12-22 | GSE138432 | GEO

RNAseq for finding splicing events in Arabidopsis prefoldin and lsm8 mutants in different environmental conditions

Project description:RNAseq for finding splicing events in Arabidopsis prefoldin and lsm8 mutants in different environmental conditions

| PRJNA513852 | ENA

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Project description:RNAseq profiling of eight transcription factor mutants during germination in Arabidopsis, at 24 h in the light (after 48h of stratification).

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RNAseq for finding splicing events in Arabidopsis prefoldin and lsm8 mutants in different environmental conditions

Project description:This GEO submission includes RNAseq raw data (fastq) and processed data (using ASpli 1.6.0) from samples obtained in the wild type and the single prefoldin4 and lsm8 mutants in three different environmental conditions as well as in the triple prefoldin2 prefoldin4 prefoldin6 mutant growth in standard conditions.

2019-01-09 | GSE124812 | GEO

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ChIP-seq data of prefoldin subunit PFDN5 in HCT116 human colon carcinoma cells

Project description:Prefoldin is a heterohexameric complex conserved from archaea to humans that plays a cochaperone role during the co-translational folding of actin and tubulin monomers. Additional functions of prefoldin in the cell nucleus have been described, including a positive contribution to transcription elongation and chromatin dynamics in yeast. Here we show that prefoldin perturbations provoked transcriptional alterations across the genome of human cells. We detected genome-wide prefoldin binding to transcribed genes and found that this binding negatively correlate with the impact of prefoldin depletion on gene expression. Moreover, lack of prefoldin caused significant global decrease in the levels of Ser2 and Ser5 phosphorylation of the RNA polymerase II carboxy-terminal domain (CTD). Altogether the reported results indicate that human prefoldin is able to act locally on the genome to modulate gene expression by influencing phosphorylation of elongating RNA polymerase II, and thereby regulating co-transcriptional splicing.

2021-05-04 | GSE171466 | GEO

RNAseq analysis of early touch responses in myc234 mutants in Arabidopsis

Project description:RNAseq analysis of early touch responses in myc234 mutants in Arabidopsis

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RNAseq of wild type Col-0 Arabidopsis plants and piezo/feronia/camta3 mutants before and 22 minutes after touch treatment

Project description:RNAseq of wild type Col-0 Arabidopsis plants and piezo/feronia/camta3 mutants before and 22 minutes after touch treatment with a gentle paint brush. The mutants were defective in genes involved in mechanosensing and downstream signalling. Their contribution to touch-responsive signalling was assessed by transcriptome analysis.

2022-08-21 | E-MTAB-10920 | biostudies-arrayexpress

Analysis of arabidopsis mutants tor/lst8/yak1/maktor

Project description:ngs2018_05_tor-analysis of arabidopsis mutants tor/lst8/yak1/maktor-Analysis of Arabidopsis insertion and suppressor mutants linked to the TOR signaling pathway.-Comparison of in vitro grown plantlets for lst8, yak1 mutants and double mutants corresponding to suppressor lines. Comparison of in vitro grown plantlets for mutants affected in LST8 interacting proteins (MAKTOR) compared to wild type.

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Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans

Project description:Heat shock factor 1 (HSF-1) and forkhead box O (FOXO) are key transcription factors that protect cells from various stresses. InCaenorhabditis elegans, HSF-1 and FOXO together promote a long life span when insulin/IGF-1 signaling (IIS) is reduced. However, it remains poorly understood how HSF-1 and FOXO cooperate to confer IIS-mediated longevity. Here, we show that prefoldin 6 (PFD-6), a component of the molecular chaperone prefoldin-like complex, relays longevity response from HSF-1 to FOXO under reduced IIS. We found that PFD-6 was specifically required for reduced IIS-mediated longevity by acting in the intestine and hypodermis. We showed that HSF-1 increased the levels of PFD-6 proteins, which in turn directly bound FOXO and enhanced its transcriptional activity. Our work suggests that the prefoldin-like chaperone complex mediates longevity response from HSF-1 to FOXO to increase the life span in animals with reduced IIS.

2023-10-04 | GSE244495 | GEO

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