Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

FBXW7 is a defining driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition

ABSTRACT: FBXW7 is a defining driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition

PROVIDER: PRJNA576165 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10237653.fastq.gz	Fastqsanger.gz
	SRR10237654.fastq.gz	Fastqsanger.gz
	SRR10237655.fastq.gz	Fastqsanger.gz
	SRR10237656.fastq.gz	Fastqsanger.gz
	SRR10237657.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

FBXW7 is a defining driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition

Project description:Fbxw7 is a tumor supressor frequently mutated in endometrial cancer. To analyze the signaling pathways that can be altered by Fbxw7 we compared RNA expression in the presence or absence of Fbxw7 in mouse endometrial cancer cells deficient for Fbxw7 and Pten.

2019-11-11 | GSE138490 | GEO

Project description:FBXW7 is a defining driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition

| PRJNA543538 | ENA

Fbxw7 is a driver of uterine carcinosarcoma by promoting epithelial-mesenchymal transition.

Project description:Uterine carcinosarcoma is an aggressive variant of endometrial carcinoma characterized by unusual histologic features including discrete malignant epithelial and mesenchymal components (carcinoma and sarcoma). Recent studies have confirmed a monoclonal origin, and comprehensive genomic characterizations have identified mutations such as Tp53 and Pten However, the biological origins and specific combination of driver events underpinning uterine carcinosarcoma have remained mysterious. Here, we explored the role of the tumor suppressor Fbxw7 in endometrial cancer through defined genetic model systems. Inactivation of Fbxw7 and Pten resulted in the formation of precancerous lesions (endometrioid intraepithelial neoplasia) and well-differentiated endometrioid adenocarcinomas. Surprisingly, all adenocarcinomas eventually developed into definitive uterine carcinosarcomas with carcinomatous and sarcomatous elements including heterologous differentiation, yielding a faithful genetically engineered model of this cancer type. Genomic analysis showed that most tumors spontaneously acquired Trp53 mutations, pointing to a triad of pathways (p53, PI3K, and Fbxw7) as the critical combination underpinning uterine carcinosarcoma, and to Fbxw7 as a key driver of this enigmatic endometrial cancer type. Lineage tracing provided formal genetic proof that the uterine carcinosarcoma cell of origin is an endometrial epithelial cell that subsequently undergoes a prominent epithelial-mesenchymal transition underlying the attainment of a highly invasive phenotype specifically driven by Fbxw7.

| S-EPMC6926017 | biostudies-literature

T-cell receptor repertoire in uterine and ovarian carcinosarcoma

Project description:T-cell receptor repertoire in uterine and ovarian carcinosarcoma

| PRJNA649236 | ENA

T-cell receptor repertoire in uterine and ovarian carcinosarcoma

Project description:Carcinosarcoma of the uterus or ovary is a rare, biphasic tumor comprising epithelial and mesenchymal elements, and exhibits aggressive clinical features. Four molecular subtypes of carcinosarcoma (POLE, MSI, CNH, and CNL) were recently established and shown to be associated with multiple clinicopathological parameters including patient outcomes. Immune microenvironment analyses on CS samples was performed using immune cell profiling with T-cell receptor repertoire assay. Carcinoma and sarcoma elements from CS samples were also assessed separately.

2020-12-01 | GSE155276 | GEO

Whole-genome DNA methylation profiling identifies epigenetic signatures of uterine carcinosarcoma

Project description:Uterine carcinosarcoma (UCS) is a form of endometrial cancer simultaneously exhibiting carcinomatous and sarcomatous elements, but the underlying molecular and epigenetic characteristic of this disease is poorly understood. We generated complete DNA methylomes for both the carcinomatous and the sarcomatous components of three UCS samples separated by laser capture microdissection and compared DNA methylomes of UCS with that of normal endometrium as well as methylomes derived from endometrioid carcinoma, serous endometrial carcinoma, and endometrial stromal sarcoma. We identified epigenetic lesions specific to carcinosarcoma, and specific to two components. Hallmarks of DNA methylation abnormality of UCS included global hypomethylation, especially in repetitive elements, and hypermethylation of tumor suppressor gene promoters. Among these, aberrant DNA methylation of MIR200 genes is a key feature of UCS. The carcinoma component of UCS was characterized by hypermethylation of promoters of EMILIN1, NEFM and CLEC14A, genes that are associated with tumor vascularization. In contrast, DNA methylation changes of PKP3, FAM83F and TCP11 were more characteristic of the sarcoma components. Our findings highlight the epigenetic signatures that distinguish the two components of UCS, providing a valuable resource for investigation of these diseases.

2017-03-08 | GSE86505 | GEO

Identification of driver genes in uterine leiomyosarcoma: low-coverage WGS

Project description:Low coverage whole-genome sequencing have been performed on uterine leiomyosarcoma to uncovered novel potential driver genes and recurrently affected pathways.

2018-07-02 | E-MTAB-5763 | biostudies-arrayexpress

FBXW7

Project description:FBXW7

| PRJNA783287 | ENA

Affymetrix gene expression profiling of GEMM uteri with perturbation of Pten and Fbxw7 at 8 weeks age

Project description:Mice with (i) PR-Cre; (ii) PR-Cre, Fbxw7 R482Q/+; (iii) PR-Cre, Pten fl/fl; (iv) PR-Cre, Pten fl/fl, Fbxw7 R482Q/+ Uterine RNA was harvested at 8 weeks age and expression profiling done by Affymetrix Clariom S Mouse HT array

2023-07-01 | GSE232356 | GEO

Identification of driver genes in uterine leiomyosarcoma: RNA seq

Project description:Identification of driver genes in uterine leiomyosarcoma: RNA seq

| PRJEB21003 | ENA