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Clonally expanded T cells reveal immunogenicity of rhabdoid tumors

ABSTRACT: Clonally expanded T cells reveal immunogenicity of rhabdoid tumors

PROVIDER: PRJNA576727 | ENA |

REPOSITORIES: ENA

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Clonally expanded T cells reveal immunogenicity of rhabdoid tumors

Project description:Clonally expanded T cells reveal immunogenicity of rhabdoid tumors

| PRJNA576726 | ENA

Natural and cryptic peptides dominate the immunopeptidome of atypical teratoid rhabdoid tumors.

Project description:Atypical teratoid/rhabdoid tumors (AT/RT) are highly aggressive CNS-tumors of infancy and early childhood. Hallmark is the surprisingly simple genomics with a truncating mutation in the SMARCB1 gene as the oncogenic driver. Nevertheless, AT/RTs are infiltrated by immune cells and even clonally expanded T-cells. However, it is unclear, what T-cells might recognize on AT/RT cells. Here, we report a comprehensive analysis of naturally presented HLA-class-I and class-II ligands on n=23 AT/RTs. MS-based analysis of the HLA-ligandome revealed 55 class-I and 139 class-II peptides from tumor-associated proteins.

2022-05-31 | PXD033935 | Pride

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid

Project description:Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid

| PRJNA555618 | ENA

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [CSF]

Project description:Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [CSF]

| PRJNA557207 | ENA

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TEMRA]

Project description:Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TEMRA]

| PRJNA555620 | ENA

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TCR-seq]

Project description:Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TCR-seq]

| PRJNA557227 | ENA

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [CSF]

Project description:Alzheimer’s disease (AD) is an age-related neurodegenerative disorder in which neuroinflammation plays a critical function. Recurring viral infections and loss of immune competence increase risk for developing AD, yet the cellular and molecular mechanisms driving these immune changes are unknown. Here we performed mass cytometry of peripheral blood mononuclear cells and detected an immunologic signature of AD characterized by increased numbers of CD8+ T effector memory CD45RA+ (TEMRA) cells. CD8+ TEMRA cells were negatively associated with cognition and single cell RNA sequencing revealed their cytotoxic effector function. Strikingly, we discovered identical, shared T cell receptors (TCRs) of clonally expanded CD8+ TEMRA cells in cerebrospinal fluid (CSF) of three AD patients. Deep TCR sequencing, machine learning, and peptide screens identified the HLA-B*08:01-restricted Epstein-Barr virus trans-activator protein BZLF1 as the cognate antigen of a novel AD CSF TCR . These results provide the first evidence of clonal, antigen-specific T cells patrolling the intrathecal space of brains affected by age-related neurodegeneration

2019-11-04 | GSE134577 | GEO

Clonally expanded CD8 T cells patrol Alzheimer's cerebrospinal fluid [TEMRA]

2019-11-04 | GSE134576 | GEO

Clonally expanded, GPR15-expressing pathogenic effector Th2 cells are associated with eosinophilic esophagitis

Project description:Clonally expanded, GPR15-expressing pathogenic effector Th2 cells are associated with eosinophilic esophagitis

| PRJNA734315 | ENA