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Sex-specific role for the long non-coding RNA linc00473 in depression

ABSTRACT: Sex-specific role for the long non-coding RNA linc00473 in depression

PROVIDER: PRJNA576745 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10255653_1.fastq.gz	Fastqsanger.gz
	SRR10255653_2.fastq.gz	Fastqsanger.gz
	SRR10255654_1.fastq.gz	Fastqsanger.gz
	SRR10255654_2.fastq.gz	Fastqsanger.gz
	SRR10255655_1.fastq.gz	Fastqsanger.gz

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Sex-specific role for the long non-coding RNA linc00473 in depression

Project description:Depression is a common disorder that affects women at twice the rate of men. Here we report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts, represent about one-third of the differentially expressed genes in the brains of depressed humans, and display complex region- and sex-specific patterns of regulation. We identified the primate-specific, neuronal-enriched gene, linc00473, as downregulated in prefrontal cortex of depressed females but not males. Using viral-mediated gene transfer to express linc00473 in mouse prefrontal cortex neurons, we mirrored the human sex-specific phenotype by inducing stress resilience solely in female mice. This sex-specific phenotype was accompanied by changes in synaptic function and gene expression selectively in female mice and, along with studies of human neuron-like cells in culture, implicates linc00473 as a CREB effector. Together, our studies identify linc00473 as a female-specific driver of stress resilience that is aberrant in female depression.

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Sex-Specific Role for the Long Non-coding RNA LINC00473 in Depression.

Project description:Depression is a common disorder that affects women at twice the rate of men. Here, we report that long non-coding RNAs (lncRNAs), a recently discovered class of regulatory transcripts, represent about one-third of the differentially expressed genes in the brains of depressed humans and display complex region- and sex-specific patterns of regulation. We identified the primate-specific, neuronal-enriched gene LINC00473 as downregulated in prefrontal cortex (PFC) of depressed females but not males. Using viral-mediated gene transfer to express LINC00473 in adult mouse PFC neurons, we mirrored the human sex-specific phenotype by inducing stress resilience solely in female mice. This sex-specific phenotype was accompanied by changes in synaptic function and gene expression selectively in female mice and, along with studies of human neuron-like cells in culture, implicates LINC00473 as a CREB effector. Together, our studies identify LINC00473 as a female-specific driver of stress resilience that is aberrant in female depression.

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