Expression data from murine gut and spleen tissues
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA577126 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:TIM-1 is a gene that regulates immune responses including transplantation tolerence, allergy and asthma, autoimmunity, viral infections as well as cancer, however its role in transplantation has not been evaluated. Here we use a murine model of graft versus host disease (GVHD) to evaluate the therapeutic potential of blocking TIM-1 using an antibody. We used microarray data to look for difference in gene expession in the gut which is one of the main organs that are afffected by GVHD as well as the spleen an organ when the immune response is generated. This will give us evidence as to whether the blocking TIM-1 mAb may modulate the immune response and protects against GVHD and promoted a less proinflammatory immune response
2019-10-12 | GSE138785 | GEO
Project description:Metabolites were extracted (aqueous & organic) from hamster tissues (liver, gut, and spleen) and were run through LC-MS, C8 in positive and negative mode.
2020-08-21 | MSV000085991 | GNPS
Project description:Metabolites were extracted (aqueous & organic) from hamster tissues (liver, gut, and spleen) and were run through LC-MS, C8 in positive and negative mode.
2020-08-21 | MSV000085990 | GNPS
Project description:CD11b+ cell populations, especially macrophages are highly heterogeneous tissue resident immune cells in both mice and human. Exact subsets and their phenotype remain unknown. We here analyzed gut CD11b+ cell populations using scRNA-seq in normal, inflamed and Nlrc4 deficient mice. There existed twelve CD11b+ cell populations and subsets in SPF mice. These CD11b+ subsets were changeable dependent on inflammation and gut environment. We found consistent high expression of Ly6C, Cd62L, previously undescribed Trem1 and Ccr7 in Ly6Chigh macrophages and Cd206 and Cx3cr1 in Ly6Clow/neg cell population in different mice. However, signature genes showed that resident macrophages but not inflammatory macrophages were highly conserved in normal and inflamed mice. Gut microbiota play a role in accumulation and differentiation of gut macrophages. Both Ly6Chigh and Ly6Clow macrophages in intestine and colon tissues are similar. These uncover the transcriptional landscape and phenotypic heterogeneity of CD11b+ cells, especially macrophages in gut tissues.
2019-10-16 | GSE138902 | GEO
Project description:Gene expression of murine DCs from bone marrow and spleen
| PRJNA758582 | ENA
Project description:Hox genes are required for the development of the intestinal caecum, a major organ of species eating plants. We have analysed the transcriptional regulation of Hoxd genes in caecal buds and show that they are controlled by a series of enhancers located in a gene desert telomeric to the HoxD cluster. The start site of two neighboring and opposite long non-coding RNAs, Hotdog and Twin of Hotdog, specifically transcribed in the caecum, contacts the expressed Hoxd genes in the framework of a topological domain, a large domain of interactions, which ensures a robust transcription of these genes during caecum budding. We show that hedgehogs have kept this regulatory potential despite the absence of caecum, suggesting that these enhancers are used in other developmental situations. In this context, we discuss some striking similarities between the caecum and the limb buds, suggesting the implementation of a common budding tool-kit. Transcriptional activity at the HoxD locus in the murine developing gut at E13, Differential gene expression analysis along the murine developing gut
2013-10-23 | E-GEOD-44366 | biostudies-arrayexpress
Project description:We compared gene expression profiles of murine IgG2b+ memory B cells isolated from spleen and bone marrow of C57BL/6J mice and mice obtained at a pet shop.
2016-10-01 | GSE82248 | GEO
Project description:We plan to describe different characters of LTi-like cells from distinct tissues. Also, we further compare the LTi-like cells from both Id2fl/fl and RorccreId2fl/fl mLN and gut.
2020-07-09 | GSE141689 | GEO
Project description:Dysbiosis in the gut microbiota impacts several systemic diseases. One possible mechanism is the migration of perturbed intestinal immunocytes to extra-intestinal tissues. Combining the Kaede photoconvertible mouse model and single-cell genomics, we generated a detailed map of migratory trajectories from the colon, at baseline and during intestinal and extra-intestinal inflammation. All colonic lineages emigrated from the colon in an S1P-dependent manner, dominated by B lymphocytes with a large continuous circulation of follicular B cells, which carried a gut-imprinted transcriptomic signature. T cell emigration was more selective, with distinct groups of RORg+ cells and IEL-like CD160+ T cells in the spleen. Gut inflammation curtailed emigration, except for DCs disseminating to lymph nodes. Colon emigrating cells distributed differentially to tumor, skin inflammation, or arthritic synovium, the former dominated by myeloid cells in a chemokine-dependent manner. These results thus reveal specific cellular trails originating in the gut, influenced by microbiota, which can shape peripheral immunity.
2023-09-13 | GSE216928 | GEO
Project description:The immunotoxicity of PFOS (perfluorooctane sulfonate) were reported previously, however, the detailed toxic mechanism remain unknown. Spleen is an important immune organ that controls the differentiation and development of immune cells including T cells, B cells, and macrophages etc. the disruption of the organ may result in altered immune functions and immunotoxicity. We used microarrays to snapshot the changes of global gene expression, and identified target genes underlying the immunotoxicity of PFOS exposure.
2013-08-20 | GSE50001 | GEO