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Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice

ABSTRACT: Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice

PROVIDER: PRJNA577661 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10279665_1.fastq.gz	Fastqsanger.gz
	SRR10279665_2.fastq.gz	Fastqsanger.gz
	SRR10279666_1.fastq.gz	Fastqsanger.gz
	SRR10279666_2.fastq.gz	Fastqsanger.gz
	SRR10279667_1.fastq.gz	Fastqsanger.gz

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Tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Tumour-exposed Tregs from IL33 genetical deficient mice

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Transposition of native chromatin (ATACseq) of tumour-exposed Tregs from IL33 genetical deficient mice

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Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Our purpose was to analyse the transcriptomic profile of Tregs from tumor-draining lymph nodes of melanoma-bearing mice in order to understand the functional difference between WT and il33-/- Tregs

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Transposition of native chromatin (ATACseq) of tumour-exposed Tregs from IL33 genetical deficient mice

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Tumour-exposed Tregs from IL33 genetical deficient mice

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Proteomic analysis of IL33-proximal proteins in squamous cell carcinoma cells

Project description:Focal adhesion kinase (FAK) is required for the expression of pro-inflammatory genes that inhibit anti-tumour immunity. Here, we show a novel and crucial role for the dual-function cytokine IL33 in FAK-dependent immune evasion. Specifically, nuclear FAK is required for the expression of IL33, the chemokine Ccl5 and the soluble form of the IL33 receptor, sST2, which are required for evasion of CD8+ T-cell-mediated anti-tumour immunity. Mechanistically, nuclear IL33 associates with FAK and a network of chromatin modifiers and transcriptional regulators, including Taf9, WDR82 and BRD4, while sST2 likely negates effects of IL33 secreted into the tumour microenvironment by infiltrating host immune cells. Finally, protein interaction network analysis implies that nuclear FAK–IL33 complexes impact on transcription factors that regulate NFkB and chemokines like Ccl5 downstream. Our data therefore provide new mechanistic insight into how FAK controls the tumour immune environment via a FAK–IL33/sST2 pathway and demonstrate a novel role for nuclear IL33 downstream of FAK as a component of transcription regulatory complexes that critically modulate anti-tumour immunity.

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Gene expression profile of regulatory T cells (Tregs) isolated from visceral adipose tissue and lymph nodes of mice sufficient and deficient of Pparg expression in Tregs

Project description:We identified Pparg as a major orchestrator of the phenotype of adipose-tissue resident regulatory T cells (VAT Tregs). To establish the role of Pparg in shaping the VAT Tregs gene profile and cell dynamics, Tregs from lymph nodes and visceral adipose tissue of mice sufficient and deficient of Pparg expression in Tregs were double sorted for microarray analysis. All gene expression profiles were obtained from highly purified (double-sorted) T cell populations sorted by flow cytometry. To reduce variability, cells from multiple mice were pooled. Triplicates were generated for all groups. Raw data were preprocessed with the RMA algorithm in GenePattern and averaged expression values were used for analysis.

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Gene expression profile of regulatory T cells (Tregs) isolated from visceral adipose tissue and lymph nodes of mice sufficient and deficient of Pparg expression in Tregs

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Transcriptional analysis of LAG3 deficient Tregs in an inflamed CNS

Project description:Transcriptional analysis of LAG3 deficient Tregs in an inflamed CNS

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