Project description:We evaluated the profile of lncRNA and mRNA expression in control and 50μg/ml DEP treated HBE cells using the Arraystar Human LncRNA Array v3.0 array,7th generation. Our findings implicates that dysregulation of mitochondria invovled mRNAs may play important role in cytotoxicity of DEP. Examination of lncRNA and mRNA expression in control or DEP-treated HBE cells
Project description:We evaluated the profile of lncRNA and mRNA expression in control and 50μg/ml DEP treated HBE cells using the Arraystar Human LncRNA Array v3.0 array,7th generation. Our findings implicates that dysregulation of mitochondria invovled mRNAs may play important role in cytotoxicity of DEP.
Project description:To identify the direct targets of circDNA2 in chronic PM2.5 exposed HBE cells, we performed RNA sequencing (RNA-seq) using RNA isolated from chronic PM2.5 exposed HBE cells or circDNA2 knockdown chronic PM2.5 exposed HBE cells (NC n=3 vs. KD n=3)
Project description:To further explore the potential mechanism underlying PM2.5-induced lung tumorigenesis, we performed circRNA sequencing (circRNA-seq) using RNA isolated from control or chronic PM2.5 exposed HBE cells (control n=3 vs. PM2.5 n=3)
Project description:mRNAs and LncRNAs have been implicated in the regulation of a board range of biological processes including development, immunity and inflammation We used mRNA and LncRNA microarray to explore the detailed biological processes and mechanisms underlying matter-induced pulmonary toxicity
Project description:miRNAs have been implicated in the regulation of a broad range of biological processes including development, immunity and inflammation We used miRNA microarray to explore the detailed biological processes and mechanisms underlying matter-induced pulmonary toxicity
Project description:The present study aimed to investigate the human serum proteome wide interaction of aluminium oxide nanoparticles (Al2O3-NPs). Methodologically, the specific interaction of serum proteins with Al2O3-NPs were explored through high resolution proteomic profiling. Here we employed LC-MS/MS based HRMS protocol to explore the list of interacted proteins. Further, novel human serum proteins interacted with Al2O3-NPs and its associated molecular pathways have been illustrated.