Project description:European-American individuals of the GENOA cohort participating in the “Genetics of Microangiopathic Brain Injury” substudy, which investigates the genetic basis of alteration in brain structure detectable by magnetic resonance imaging. This analysis investigated the association of gene expression with age (at the time of cell transformation). Participants in this study are drawn from the GENOA study, a population-based study from Rochester, MN

2013-09-15 | E-GEOD-49531 | biostudies-arrayexpress

Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylation450 BeadChip

Project description:Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylation450 BeadChip

| PRJNA864862 | ENA

Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylationEPIC BeadChip

Project description:Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylationEPIC BeadChip

| PRJNA864863 | ENA

Tumor Immunobiological Differences in Prostate Cancer between African-American and European-American Men

Project description:The incidence and mortality rates of prostate cancer are significantly higher in African-American men when compared to European-American men. We tested the hypothesis that differences in tumor biology contribute to this survival health disparity. Using microarray technology, we obtained gene expression profiles of primary prostate tumors resected from 33 African-American and 36 European-American patients. These tumors were matched on clinical parameters. We also evaluated 18 non-tumor prostate tissues from 7 African-American and 11 European-American patients. The resulting datasets were analyzed for expression differences on the gene and pathway level comparing African-American with European-American patients. Our analysis revealed a significant number of genes, e.g., 162 transcripts at a false-discovery rate less than 5%, to be differently expressed between African-American and European-American patients. Using a disease association analysis, we identified a common relationship of these transcripts with autoimmunity and inflammation. These findings were corroborated on the pathway level with numerous differently expressed genes clustering in immune response, stress response, cytokine signaling, and chemotaxis pathways. Furthermore, a two-gene tumor signature was identified that accurately differentiated between African-American and European-American patients. This finding was confirmed in a blinded analysis of a second sample set. In conclusion, the gene expression profiles of prostate tumors indicate prominent differences in tumor immunobiology between African-American and European-American men. The profiles portray the existence of a distinct tumor microenvironment in these two patient groups. Keywords: Microdissected tissue analysis

2008-01-01 | GSE6956 | GEO

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