Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Muscle specific MyD88-/- confers a sexual dimorphism protecting female mice from inactivity-induced fat accumulation

ABSTRACT: Muscle specific MyD88-/- confers a sexual dimorphism protecting female mice from inactivity-induced fat accumulation

PROVIDER: PRJNA577857 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10292001_1.fastq.gz	Fastqsanger.gz
	SRR10292001_2.fastq.gz	Fastqsanger.gz
	SRR10292002_1.fastq.gz	Fastqsanger.gz
	SRR10292002_2.fastq.gz	Fastqsanger.gz
	SRR10292003_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 64

Similar Datasets

Muscle specific MyD88-/- confers a sexual dimorphism protecting female mice from inactivity-induced fat accumulation

Project description:We demonstrate whole body inflammation (miR146a-/-) exacerbated inactivity-induced fat gain and glucose dysregulation, while muscle specific MyD88 KO mitigated these outcomes in female mice. Higher gene expression of Igf1 and decreased expression of Ip6k3 in muscle of MyD88 KO female mice may explain enhancement of glucose uptake in the soleus. Whereas protection from fat accumulation may be related to visceral fat gene changes in adipose tissue expansion (Prc1↓, Gulp1↑, Anxa2↓, Cav2↓, EHD1↓), adipose beiging (Fgf10↑), metainflammation (Hmox1↓), and genes involved in perfusion. Of noteworthy to mention, two genes decreased in common between muscle and fat with the ablation of muscle MyD88. These were expression of the negative regulator for GLUT4 translocation, Ralgapa2, and uncharacterized 993011J21Rik2, a potential interferon interacting gene. We conclude that future therapeutic strategies for prevention or treatment of obesity and metabolic disturbances in populations unable to be physically active should focus on further understanding how skeletal muscle inflammation communicates with fat storage depots, and how this cross-talk is influenced by sex hormones.

2019-12-30 | GSE138940 | GEO

Sexual dimorphism in mice

Project description:Sexual dimorphism in mice

| PRJEB2572 | ENA

Sexual dimorphism in osteogenic differentiation

Project description:Sexual dimorphism in osteogenic differentiation

| PRJNA768873 | ENA

Sexual dimorphism in gene expression in two species of songbirds

Project description:We have done an expression experiment studying sexual dimorphism in gene expression in two species of songbirds, the zebra finch (Teaniopigia guttata) and the common whitethroat (Sylvia communis).

2010-11-30 | E-MEXP-2914 | biostudies-arrayexpress

Sexual Dimorphism of Circadian Liver Transcriptome

Project description:Sexual Dimorphism of Circadian Liver Transcriptome

| PRJNA893576 | ENA

Hepatic BCL6 and plasma triglycerides regulate sexual dimorphism in tissue tolerance [set 2]

Project description:Hepatic gene expression shows sexual dimorphism. Here, we investigated the role of BCL6 in establishing sexual dimorphism in hepatic gene expression and created Bcl6Flox/Flox,Alb-Cre mice and performed RNAseq from livers of 4- and 8-week-old male and female Ctrl and BCL6 liver knock-out mice.

2022-10-21 | GSE138391 | GEO

Silene Sexual Dimorphism QTL

Project description:Insights into the genetic architecture of sexual dimorphism from an interspecific cross between two diverging Silene (Caryophyllaceae) species

| PRJEB34584 | ENA

Sexual dimorphism in human immune system aging

Project description:Sexual dimorphism in human immune system aging

| PRJNA591038 | ENA

Sexual dimorphism in human immune system aging

Project description:Sexual dimorphism in human immune system aging

| PRJNA591039 | ENA

Transcriptome Analysis of Sexual Dimorphism in the Chinese White Wax Scale Ericerus pela Using RNA-seq

Project description:We constructed eight libraries of female and male E. pela at different developmental stages using RNA-seq technology. Many genes and pathways related to sexual dimorphism were identified.The female and male E. pela take different developmental patterns. The sexual dimorphism in E. pela may involve many different regulatory components. Female and male E. pela at different developmental stages using RNA-seq technology

2013-11-09 | E-GEOD-52228 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data